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Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck

BACKGROUND: Feathers with complex and fine structure are hallmark avian integument appendages, which have contributed significantly to the survival and breeding for birds. Here, we aimed to explore the differentiation, morphogenesis and development of diverse feathers in the domestic duck. RESULTS:...

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Autores principales: Yang, Jing, Qu, Yanhua, Huang, Yuan, Lei, Fumin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968480/
https://www.ncbi.nlm.nih.gov/pubmed/29793441
http://dx.doi.org/10.1186/s12864-018-4778-7
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author Yang, Jing
Qu, Yanhua
Huang, Yuan
Lei, Fumin
author_facet Yang, Jing
Qu, Yanhua
Huang, Yuan
Lei, Fumin
author_sort Yang, Jing
collection PubMed
description BACKGROUND: Feathers with complex and fine structure are hallmark avian integument appendages, which have contributed significantly to the survival and breeding for birds. Here, we aimed to explore the differentiation, morphogenesis and development of diverse feathers in the domestic duck. RESULTS: Transcriptome profiles of skin owing feather follicle from two body parts at three physiological stages were constructed to understand the molecular network and excavate the candidate genes associated with the development of plumulaceous and flight feather structures. The venn analysis of differentially expressed genes (DEGs) between abdomen and wing skin tissues at three developmental stages showed that 38 genes owing identical differentially expression pattern. Together, our data suggest that feather morphological and structural diversity can be possibly related to the homeobox proteins. The key series-clusters, many candidate biological processes and genes were identified for the morphogenesis, growth and development of two feather types. Through comparing the results of developmental transcriptomes from plumulaceous and flight feather, we found that DEGs belonging to the family of WNT, FGF and BMP have certain differences; even the consistent DEGs of skin and feather follicle transcriptomes from abdomen and wing have the different expression patterns. CONCLUSIONS: Overall, this study detected many functional genes and showed differences in the molecular mechanisms of diverse feather developments. The findings in WNT, FGF and BMP, which were consistent with biological experiments, showed more possible complex modulations. A correlative role of HOX genes was also suggested but future biological verification experiments are required. This work provided valuable information for subsequent research on the morphogenesis of feathers. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-018-4778-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-59684802018-05-30 Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck Yang, Jing Qu, Yanhua Huang, Yuan Lei, Fumin BMC Genomics Research Article BACKGROUND: Feathers with complex and fine structure are hallmark avian integument appendages, which have contributed significantly to the survival and breeding for birds. Here, we aimed to explore the differentiation, morphogenesis and development of diverse feathers in the domestic duck. RESULTS: Transcriptome profiles of skin owing feather follicle from two body parts at three physiological stages were constructed to understand the molecular network and excavate the candidate genes associated with the development of plumulaceous and flight feather structures. The venn analysis of differentially expressed genes (DEGs) between abdomen and wing skin tissues at three developmental stages showed that 38 genes owing identical differentially expression pattern. Together, our data suggest that feather morphological and structural diversity can be possibly related to the homeobox proteins. The key series-clusters, many candidate biological processes and genes were identified for the morphogenesis, growth and development of two feather types. Through comparing the results of developmental transcriptomes from plumulaceous and flight feather, we found that DEGs belonging to the family of WNT, FGF and BMP have certain differences; even the consistent DEGs of skin and feather follicle transcriptomes from abdomen and wing have the different expression patterns. CONCLUSIONS: Overall, this study detected many functional genes and showed differences in the molecular mechanisms of diverse feather developments. The findings in WNT, FGF and BMP, which were consistent with biological experiments, showed more possible complex modulations. A correlative role of HOX genes was also suggested but future biological verification experiments are required. This work provided valuable information for subsequent research on the morphogenesis of feathers. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12864-018-4778-7) contains supplementary material, which is available to authorized users. BioMed Central 2018-05-24 /pmc/articles/PMC5968480/ /pubmed/29793441 http://dx.doi.org/10.1186/s12864-018-4778-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yang, Jing
Qu, Yanhua
Huang, Yuan
Lei, Fumin
Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck
title Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck
title_full Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck
title_fullStr Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck
title_full_unstemmed Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck
title_short Dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck
title_sort dynamic transcriptome profiling towards understanding the morphogenesis and development of diverse feather in domestic duck
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968480/
https://www.ncbi.nlm.nih.gov/pubmed/29793441
http://dx.doi.org/10.1186/s12864-018-4778-7
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