Cargando…

White matter microstructure is altered in cognitively normal middle-aged APOE-ε4 homozygotes

BACKGROUND: The ε4 allele of the apolipoprotein E gene (APOE-ε4) is the strongest genetic factor for late-onset Alzheimer’s disease. During middle age, cognitively healthy APOE-ε4 carriers already show several brain alterations that resemble those of Alzheimer's disease (AD), but to a subtler d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Operto, Grégory, Cacciaglia, Raffaele, Grau-Rivera, Oriol, Falcon, Carles, Brugulat-Serrat, Anna, Ródenas, Pablo, Ramos, Rubén, Morán, Sebastián, Esteller, Manel, Bargalló, Nuria, Molinuevo, José Luis, Gispert, Juan Domingo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968505/ https://www.ncbi.nlm.nih.gov/pubmed/29793545 http://dx.doi.org/10.1186/s13195-018-0375-x

Ejemplares similares

Interactive effect of age and APOE-ε4 allele load on white matter myelin content in cognitively normal middle-aged subjects
por: Operto, Grégory, et al.
Publicado: (2019)

APOE-ε4 risk variant for Alzheimer's disease modifies the association between cognitive performance and cerebral morphology in healthy middle-aged individuals
por: Cacciaglia, Raffaele, et al.
Publicado: (2019)

APOE-ε4 Shapes the Cerebral Organization in Cognitively Intact Individuals as Reflected by Structural Gray Matter Networks
por: Cacciaglia, Raffaele, et al.
Publicado: (2020)

Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation
por: Cacciaglia, Raffaele, et al.
Publicado: (2022)

Association between insomnia and cognitive performance, gray matter volume, and white matter microstructure in cognitively unimpaired adults
por: Grau-Rivera, Oriol, et al.
Publicado: (2020)

Episodic memory and executive functions in cognitively healthy individuals display distinct neuroanatomical correlates which are differentially modulated by aging
por: Cacciaglia, Raffaele, et al.
Publicado: (2018)

Nonlinear interaction between APOE ε4 allele load and age in the hippocampal surface of cognitively intact individuals
por: Martí‐Juan, Gerard, et al.
Publicado: (2020)

Effect of BDNF Val66Met on hippocampal subfields volumes and compensatory interaction with APOE-ε4 in middle-age cognitively unimpaired individuals from the ALFA study
por: Vilor-Tejedor, Natalia, et al.
Publicado: (2020)

APOE-ε4 modulates the association between regional amyloid deposition and cognitive performance in cognitively unimpaired middle-aged individuals
por: Brugulat-Serrat, Anna, et al.
Publicado: (2023)

Age, sex and APOE-ε4 modify the balance between soluble and fibrillar β-amyloid in non-demented individuals: topographical patterns across two independent cohorts
por: Cacciaglia, Raffaele, et al.
Publicado: (2022)

White matter hyperintensities mediate gray matter volume and processing speed relationship in cognitively unimpaired participants
por: Brugulat‐Serrat, Anna, et al.
Publicado: (2019)

Longitudinal structural cerebral changes related to core CSF biomarkers in preclinical Alzheimer's disease: A study of two independent datasets
por: Falcon, Carles, et al.
Publicado: (2018)

Prediction of amyloid pathology in cognitively unimpaired individuals using voxel-wise analysis of longitudinal structural brain MRI
por: Petrone, Paula M., et al.
Publicado: (2019)

Spatial patterns of white matter hyperintensities associated with Alzheimer’s disease risk factors in a cognitively healthy middle-aged cohort
por: Salvadó, Gemma, et al.
Publicado: (2019)

Incidental findings on brain MRI of cognitively normal first-degree descendants of patients with Alzheimer's disease: a cross-sectional analysis from the ALFA (Alzheimer and Families) project
por: Brugulat-Serrat, Anna, et al.
Publicado: (2017)

NeAT: a Nonlinear Analysis Toolbox for Neuroimaging
por: Casamitjana, Adrià, et al.
Publicado: (2020)

The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals
por: Salvadó, Gemma, et al.
Publicado: (2021)

Brain and cognitive correlates of subjective cognitive decline-plus features in a population-based cohort
por: Sánchez-Benavides, Gonzalo, et al.
Publicado: (2018)

Polygenic score modifies risk for Alzheimer's disease in APOE ε4 homozygotes at phenotypic extremes
por: Huq, Aamira J., et al.
Publicado: (2021)

Patterns of white matter hyperintensities associated with cognition in middle-aged cognitively healthy individuals
por: Brugulat-Serrat, Anna, et al.
Publicado: (2019)

Distinct Cognitive and Brain Morphological Features in Healthy Subjects Unaware of Informant-Reported Cognitive Decline
por: Sánchez-Benavides, Gonzalo, et al.
Publicado: (2018)

The APOE ε4 genotype modulates CSF YKL-40 levels and their structural brain correlates in the continuum of Alzheimer's disease but not those of sTREM2
por: Gispert, Juan Domingo, et al.
Publicado: (2016)

Centiloid cut-off values for optimal agreement between PET and CSF core AD biomarkers
por: Salvadó, Gemma, et al.
Publicado: (2019)

Genetic Predisposition to Alzheimer’s Disease Is Associated with Enlargement of Perivascular Spaces in Centrum Semiovale Region
por: Ciampa, Iacopo, et al.
Publicado: (2021)

APOE ε4/ε4 homozygotes with early Alzheimer's disease show accelerated hippocampal atrophy and cortical thinning that correlates with cognitive decline
por: Abushakra, Susan, et al.
Publicado: (2020)

Management and Quality Control of Large Neuroimaging Datasets: Developments From the Barcelonaβeta Brain Research Center
por: Huguet, Jordi, et al.
Publicado: (2021)

Structural Connectivity Alterations Along the Alzheimer’s Disease Continuum: Reproducibility Across Two Independent Samples and Correlation with Cerebrospinal Fluid Amyloid-β and Tau
por: Tucholka, Alan, et al.
Publicado: (2018)

Differential associations of APOE-ε2 and APOE-ε4 alleles with PET-measured amyloid-β and tau deposition in older individuals without dementia
por: Salvadó, Gemma, et al.
Publicado: (2021)

Quantitative informant‐ and self‐reports of subjective cognitive decline predict amyloid beta PET outcomes in cognitively unimpaired individuals independently of age and APOE ε4
por: Sánchez‐Benavides, Gonzalo, et al.
Publicado: (2020)

A whole-brain computational modeling approach to explain the alterations in resting-state functional connectivity during progression of Alzheimer's disease
por: Demirtaş, Murat, et al.
Publicado: (2017)

Reference Data for Attentional, Executive, Linguistic, and Visual Processing Tests Obtained from Cognitively Healthy Individuals with Normal Alzheimer’s Disease Cerebrospinal Fluid Biomarker Levels
por: López-Martos, David, et al.
Publicado: (2023)

DHA intake relates to better cerebrovascular and neurodegeneration neuroimaging phenotypes in middle-aged adults at increased genetic risk of Alzheimer disease
por: Sala-Vila, Aleix, et al.
Publicado: (2021)

CSF glial biomarkers YKL40 and sTREM2 are associated with longitudinal volume and diffusivity changes in cognitively unimpaired individuals
por: Falcon, Carles, et al.
Publicado: (2019)

Resistance to autosomal dominant Alzheimer’s in an APOE3-Christchurch homozygote: a case report
por: Arboleda-Velasquez, Joseph F., et al.
Publicado: (2019)

Gliovascular alterations in sporadic and familial Alzheimer's disease: APOE3 Christchurch homozygote glioprotection
por: Henao‐Restrepo, Julián, et al.
Publicado: (2022)

Perivascular spaces are associated with tau pathophysiology and synaptic dysfunction in early Alzheimer’s continuum
por: Vilor-Tejedor, Natalia, et al.
Publicado: (2021)

Association of APOE Serum Levels and APOE ε2, ε3, and ε4 Alleles with Optic Neuritis
por: Momkute, Liucija, et al.
Publicado: (2022)

Brain alterations in the early Alzheimer’s continuum with amyloid-β, tau, glial and neurodegeneration CSF markers
por: Salvadó, Gemma, et al.
Publicado: (2022)

APOE-ε4-related differences in left thalamic microstructure in cognitively healthy adults
por: Mole, Jilu P., et al.
Publicado: (2020)

Reactive astrogliosis is associated with higher cerebral glucose consumption in the early Alzheimer’s continuum
por: Salvadó, Gemma, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_qj3k223m5i02igvbuplq04ebun