An effective strategy for recapitulating N-terminal heptad repeat trimers in enveloped virus surface glycoproteins for therapeutic applications

Sequestering peptides derived from the N-terminal heptad repeat (NHR) of class I viral fusion proteins into a non-aggregating trimeric coiled-coil conformation remains a major challenge. Here, we implemented a synthetic strategy to stabilize NHR-helical trimers, with the human immunodeficiency virus...

Descripción completa

Detalles Bibliográficos
Autores principales: Lai, Wenqing, Wang, Chao, Yu, Fei, Lu, Lu, Wang, Qian, Jiang, Xifeng, Xu, Xiaoyu, Zhang, Tianhong, Wu, Shengming, Zheng, Xi, Zhang, Zhenqing, Dong, Fangting, Jiang, Shibo, Liu, Keliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968561/
https://www.ncbi.nlm.nih.gov/pubmed/29899942
http://dx.doi.org/10.1039/c5sc04046a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968561/
https://www.ncbi.nlm.nih.gov/pubmed/29899942
http://dx.doi.org/10.1039/c5sc04046a

Ejemplares similares