Casein kinase 1α: biological mechanisms and theranostic potential

Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, and d...

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Detalles Bibliográficos
Autores principales: Jiang, Shaojie, Zhang, Miaofeng, Sun, Jihong, Yang, Xiaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968562/
https://www.ncbi.nlm.nih.gov/pubmed/29793495
http://dx.doi.org/10.1186/s12964-018-0236-z
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author Jiang, Shaojie
Zhang, Miaofeng
Sun, Jihong
Yang, Xiaoming
author_facet Jiang, Shaojie
Zhang, Miaofeng
Sun, Jihong
Yang, Xiaoming
author_sort Jiang, Shaojie
collection PubMed
description Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, and differentiation in development, circadian rhythm, and the immune response as well as neurodegeneration and cancer. Given its involvement in diverse cellular, physiological, and pathological processes, CK1α is a promising therapeutic target. In this review, we summarize what is known of the biological functions of CK1α, and provide an overview of existing challenges and potential opportunities for advancing theranostics.
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spelling pubmed-59685622018-05-30 Casein kinase 1α: biological mechanisms and theranostic potential Jiang, Shaojie Zhang, Miaofeng Sun, Jihong Yang, Xiaoming Cell Commun Signal Review Casein kinase 1α (CK1α) is a multifunctional protein belonging to the CK1 protein family that is conserved in eukaryotes from yeast to humans. It regulates signaling pathways related to membrane trafficking, cell cycle progression, chromosome segregation, apoptosis, autophagy, cell metabolism, and differentiation in development, circadian rhythm, and the immune response as well as neurodegeneration and cancer. Given its involvement in diverse cellular, physiological, and pathological processes, CK1α is a promising therapeutic target. In this review, we summarize what is known of the biological functions of CK1α, and provide an overview of existing challenges and potential opportunities for advancing theranostics. BioMed Central 2018-05-24 /pmc/articles/PMC5968562/ /pubmed/29793495 http://dx.doi.org/10.1186/s12964-018-0236-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Jiang, Shaojie
Zhang, Miaofeng
Sun, Jihong
Yang, Xiaoming
Casein kinase 1α: biological mechanisms and theranostic potential
title Casein kinase 1α: biological mechanisms and theranostic potential
title_full Casein kinase 1α: biological mechanisms and theranostic potential
title_fullStr Casein kinase 1α: biological mechanisms and theranostic potential
title_full_unstemmed Casein kinase 1α: biological mechanisms and theranostic potential
title_short Casein kinase 1α: biological mechanisms and theranostic potential
title_sort casein kinase 1α: biological mechanisms and theranostic potential
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968562/
https://www.ncbi.nlm.nih.gov/pubmed/29793495
http://dx.doi.org/10.1186/s12964-018-0236-z
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