Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease

The recent identification of profilin1 mutations in 25 familial ALS cases has linked altered function of this cytoskeleton-regulating protein to the pathogenesis of motor neuron disease. To investigate the pathological role of mutant profilin1 in motor neuron disease, we generated transgenic lines o...

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Detalles Bibliográficos
Autores principales: Fil, Daniel, DeLoach, Abigail, Yadav, Shilpi, Alkam, Duah, MacNicol, Melanie, Singh, Awantika, Compadre, Cesar M., Goellner, Joseph J., O’Brien, Charles A., Fahmi, Tariq, Basnakian, Alexei G., Calingasan, Noel Y., Klessner, Jodi L., Beal, Flint M., Peters, Owen M., Metterville, Jake, Brown, Robert H., Ling, Karen K.Y., Rigo, Frank, Ozdinler, P. Hande, Kiaei, Mahmoud
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968635/
https://www.ncbi.nlm.nih.gov/pubmed/28040732
http://dx.doi.org/10.1093/hmg/ddw429

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