Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity

Here, we report the complete genome sequences of human metapneumovirus (HMPV) prior to and after passaging in LLC-MK2 cells. Paired comparisons of the 13,335-nucleotide genomes revealed that the virus acquired the T10736C transition in its genome, which did not affect the amino acid sequences of HMP...

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Autores principales: Loevenich, Simon, Ianevski, Aleksandr, Oitmaa, Eneli, Kainov, Denis E., Anthonsen, Marit W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2018
Materias:
Viruses
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968720/
https://www.ncbi.nlm.nih.gov/pubmed/29798923
http://dx.doi.org/10.1128/genomeA.00440-18
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author Loevenich, Simon
Ianevski, Aleksandr
Oitmaa, Eneli
Kainov, Denis E.
Anthonsen, Marit W.
author_facet Loevenich, Simon
Ianevski, Aleksandr
Oitmaa, Eneli
Kainov, Denis E.
Anthonsen, Marit W.
author_sort Loevenich, Simon
collection PubMed
description Here, we report the complete genome sequences of human metapneumovirus (HMPV) prior to and after passaging in LLC-MK2 cells. Paired comparisons of the 13,335-nucleotide genomes revealed that the virus acquired the T10736C transition in its genome, which did not affect the amino acid sequences of HMPV proteins.
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spelling pubmed-59687202018-05-30 Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity Loevenich, Simon Ianevski, Aleksandr Oitmaa, Eneli Kainov, Denis E. Anthonsen, Marit W. Genome Announc Viruses Here, we report the complete genome sequences of human metapneumovirus (HMPV) prior to and after passaging in LLC-MK2 cells. Paired comparisons of the 13,335-nucleotide genomes revealed that the virus acquired the T10736C transition in its genome, which did not affect the amino acid sequences of HMPV proteins. American Society for Microbiology 2018-05-24 /pmc/articles/PMC5968720/ /pubmed/29798923 http://dx.doi.org/10.1128/genomeA.00440-18 Text en Copyright © 2018 Loevenich et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Viruses
Loevenich, Simon
Ianevski, Aleksandr
Oitmaa, Eneli
Kainov, Denis E.
Anthonsen, Marit W.
Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity
title Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity
title_full Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity
title_fullStr Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity
title_full_unstemmed Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity
title_short Single Passage of Human Metapneumovirus in LLC-MK2 Cells Does Not Affect Viral Protein-Coding Capacity
title_sort single passage of human metapneumovirus in llc-mk2 cells does not affect viral protein-coding capacity
topic Viruses
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968720/
https://www.ncbi.nlm.nih.gov/pubmed/29798923
http://dx.doi.org/10.1128/genomeA.00440-18
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