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Reduced Contrast Sensitivity is Associated With Elevated Equivalent Intrinsic Noise in Type 2 Diabetics Who Have Mild or No Retinopathy

PURPOSE: To evaluate explanations for contrast sensitivity (CS) losses in subjects who have mild nonproliferative diabetic retinopathy (NPDR) or no diabetic retinopathy (NDR) by measuring and modeling CS in luminance noise. METHODS: Ten diabetic subjects with NDR, 10 with mild NPDR, and 10 age-equiv...

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Autores principales: McAnany, J. Jason, Park, Jason C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968834/
https://www.ncbi.nlm.nih.gov/pubmed/29847671
http://dx.doi.org/10.1167/iovs.18-24151
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author McAnany, J. Jason
Park, Jason C.
author_facet McAnany, J. Jason
Park, Jason C.
author_sort McAnany, J. Jason
collection PubMed
description PURPOSE: To evaluate explanations for contrast sensitivity (CS) losses in subjects who have mild nonproliferative diabetic retinopathy (NPDR) or no diabetic retinopathy (NDR) by measuring and modeling CS in luminance noise. METHODS: Ten diabetic subjects with NDR, 10 with mild NPDR, and 10 age-equivalent nondiabetic controls participated. Contrast threshold energy (E(t)) was measured for letters presented in the absence of noise (E(t0)) and in four levels of luminance noise. Data were fit with the linear amplifier model to estimate inferred noise level within the visual pathway (N(eq)) and sampling efficiency (ability to use stimulus information optimally). E(t0), N(eq), and efficiency were compared to clinical characteristics. RESULTS: N(eq) was correlated with E(t0) for the diabetic subjects (r = 0.93, P < 0.001) and ranged from normal to 12-times the upper limit of normal. ANOVA indicated significant differences among the subject groups for E(t0) and N(eq) (both F > 11.92, P < 0.001). E(t0) and N(eq) were elevated for the mild NPDR group compared to the control and NDR groups (all t > 3.89, P ≤ 0.001); the NDR and control groups did not differ significantly (all t < 0.61, P > 0.55). There were no significant efficiency differences among the groups (F = 1.29, P = 0.29). N(eq) was correlated significantly with disease duration, microperimetric sensitivity, and Pelli-Robson CS. CONCLUSIONS: Elevated contrast threshold may be associated with increased intrinsic noise in early-stage diabetic subjects. Results suggest that noise-based CS measurements can provide important information about early neural dysfunction in these individuals.
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spelling pubmed-59688342018-05-29 Reduced Contrast Sensitivity is Associated With Elevated Equivalent Intrinsic Noise in Type 2 Diabetics Who Have Mild or No Retinopathy McAnany, J. Jason Park, Jason C. Invest Ophthalmol Vis Sci Visual Psychophysics and Physiological Optics PURPOSE: To evaluate explanations for contrast sensitivity (CS) losses in subjects who have mild nonproliferative diabetic retinopathy (NPDR) or no diabetic retinopathy (NDR) by measuring and modeling CS in luminance noise. METHODS: Ten diabetic subjects with NDR, 10 with mild NPDR, and 10 age-equivalent nondiabetic controls participated. Contrast threshold energy (E(t)) was measured for letters presented in the absence of noise (E(t0)) and in four levels of luminance noise. Data were fit with the linear amplifier model to estimate inferred noise level within the visual pathway (N(eq)) and sampling efficiency (ability to use stimulus information optimally). E(t0), N(eq), and efficiency were compared to clinical characteristics. RESULTS: N(eq) was correlated with E(t0) for the diabetic subjects (r = 0.93, P < 0.001) and ranged from normal to 12-times the upper limit of normal. ANOVA indicated significant differences among the subject groups for E(t0) and N(eq) (both F > 11.92, P < 0.001). E(t0) and N(eq) were elevated for the mild NPDR group compared to the control and NDR groups (all t > 3.89, P ≤ 0.001); the NDR and control groups did not differ significantly (all t < 0.61, P > 0.55). There were no significant efficiency differences among the groups (F = 1.29, P = 0.29). N(eq) was correlated significantly with disease duration, microperimetric sensitivity, and Pelli-Robson CS. CONCLUSIONS: Elevated contrast threshold may be associated with increased intrinsic noise in early-stage diabetic subjects. Results suggest that noise-based CS measurements can provide important information about early neural dysfunction in these individuals. The Association for Research in Vision and Ophthalmology 2018-05 /pmc/articles/PMC5968834/ /pubmed/29847671 http://dx.doi.org/10.1167/iovs.18-24151 Text en Copyright 2018 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
spellingShingle Visual Psychophysics and Physiological Optics
McAnany, J. Jason
Park, Jason C.
Reduced Contrast Sensitivity is Associated With Elevated Equivalent Intrinsic Noise in Type 2 Diabetics Who Have Mild or No Retinopathy
title Reduced Contrast Sensitivity is Associated With Elevated Equivalent Intrinsic Noise in Type 2 Diabetics Who Have Mild or No Retinopathy
title_full Reduced Contrast Sensitivity is Associated With Elevated Equivalent Intrinsic Noise in Type 2 Diabetics Who Have Mild or No Retinopathy
title_fullStr Reduced Contrast Sensitivity is Associated With Elevated Equivalent Intrinsic Noise in Type 2 Diabetics Who Have Mild or No Retinopathy
title_full_unstemmed Reduced Contrast Sensitivity is Associated With Elevated Equivalent Intrinsic Noise in Type 2 Diabetics Who Have Mild or No Retinopathy
title_short Reduced Contrast Sensitivity is Associated With Elevated Equivalent Intrinsic Noise in Type 2 Diabetics Who Have Mild or No Retinopathy
title_sort reduced contrast sensitivity is associated with elevated equivalent intrinsic noise in type 2 diabetics who have mild or no retinopathy
topic Visual Psychophysics and Physiological Optics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5968834/
https://www.ncbi.nlm.nih.gov/pubmed/29847671
http://dx.doi.org/10.1167/iovs.18-24151
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