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Improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study
AIM: To explore potential study participants’ views on willingness to join clinical trials of pharmacological interventions for illicit opioid use to inform and improve future recruitment strategies. DESIGN: Qualitative focus group study [six groups: oral methadone (two groups); buprenorphine tablet...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969063/ https://www.ncbi.nlm.nih.gov/pubmed/29356208 http://dx.doi.org/10.1111/add.14163 |
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author | Neale, Joanne Tompkins, Charlotte N. E. McDonald, Rebecca Strang, John |
author_facet | Neale, Joanne Tompkins, Charlotte N. E. McDonald, Rebecca Strang, John |
author_sort | Neale, Joanne |
collection | PubMed |
description | AIM: To explore potential study participants’ views on willingness to join clinical trials of pharmacological interventions for illicit opioid use to inform and improve future recruitment strategies. DESIGN: Qualitative focus group study [six groups: oral methadone (two groups); buprenorphine tablets (two groups); injectable opioid agonist treatment (one group); and former opioid agonist treatment (one group)]. SETTINGS: Drug and alcohol services and a peer support recovery service (London, UK). PARTICIPANTS: Forty people with experience of opioid agonist treatment for heroin dependence (26 males, 14 females; aged 33–66 years). MEASUREMENTS: Data collection was facilitated by a topic guide that explored willingness to enrol in clinical pharmacological trials. Groups were audio‐recorded and transcribed. Transcribed data were analysed inductively via Iterative Categorization. FINDINGS: Participants’ willingness to join pharmacological trials of medications for opioid dependence was affected by factors relating to study burden, study drug, study design, study population and study relationships. Participants worried that the trial drug might be worse than, or interfere with, their current treatment. They also misunderstood aspects of trial design despite the researchers’ explanations. CONCLUSIONS: Recruitment of participants for clinical trials of pharmacological interventions for illicit opioid use could be improved if researchers became better at explaining clinical trials to potential participants, dispelling misconceptions about trials and increasing trust in the research process and research establishment. A checklist of issues to consider when designing pharmacological trials for illicit opioid use is proposed. |
format | Online Article Text |
id | pubmed-5969063 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-59690632018-05-30 Improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study Neale, Joanne Tompkins, Charlotte N. E. McDonald, Rebecca Strang, John Addiction Research Reports AIM: To explore potential study participants’ views on willingness to join clinical trials of pharmacological interventions for illicit opioid use to inform and improve future recruitment strategies. DESIGN: Qualitative focus group study [six groups: oral methadone (two groups); buprenorphine tablets (two groups); injectable opioid agonist treatment (one group); and former opioid agonist treatment (one group)]. SETTINGS: Drug and alcohol services and a peer support recovery service (London, UK). PARTICIPANTS: Forty people with experience of opioid agonist treatment for heroin dependence (26 males, 14 females; aged 33–66 years). MEASUREMENTS: Data collection was facilitated by a topic guide that explored willingness to enrol in clinical pharmacological trials. Groups were audio‐recorded and transcribed. Transcribed data were analysed inductively via Iterative Categorization. FINDINGS: Participants’ willingness to join pharmacological trials of medications for opioid dependence was affected by factors relating to study burden, study drug, study design, study population and study relationships. Participants worried that the trial drug might be worse than, or interfere with, their current treatment. They also misunderstood aspects of trial design despite the researchers’ explanations. CONCLUSIONS: Recruitment of participants for clinical trials of pharmacological interventions for illicit opioid use could be improved if researchers became better at explaining clinical trials to potential participants, dispelling misconceptions about trials and increasing trust in the research process and research establishment. A checklist of issues to consider when designing pharmacological trials for illicit opioid use is proposed. John Wiley and Sons Inc. 2018-02-21 2018-06 /pmc/articles/PMC5969063/ /pubmed/29356208 http://dx.doi.org/10.1111/add.14163 Text en © 2018 The Authors. Addiction published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Reports Neale, Joanne Tompkins, Charlotte N. E. McDonald, Rebecca Strang, John Improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study |
title | Improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study |
title_full | Improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study |
title_fullStr | Improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study |
title_full_unstemmed | Improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study |
title_short | Improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study |
title_sort | improving recruitment to pharmacological trials for illicit opioid use: findings from a qualitative focus group study |
topic | Research Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969063/ https://www.ncbi.nlm.nih.gov/pubmed/29356208 http://dx.doi.org/10.1111/add.14163 |
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