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Synthesis of C‐14 labeled GABA(A) α2/α3 selective partial agonists and the investigation of late‐occurring and long‐circulating metabolites of GABA(A) receptor modulator AZD7325

Anxiolytic activity has been associated with GABA(A) α2 and α3 subunits. Several target compounds were identified and required in C‐14 labeled form to enable a better understanding of their drug metabolism and pharmacokinetic properties. AZD7325 is a selective GABA(A) α2 and α3 receptor modulator in...

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Detalles Bibliográficos
Autores principales:	Artelsmair, Markus, Gu, Chungang, Lewis, Richard J., Elmore, Charles S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2018
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969218/ https://www.ncbi.nlm.nih.gov/pubmed/29314165 http://dx.doi.org/10.1002/jlcr.3602

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