Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N‐(Pentafluorobenzoyloxy)carbamates

Ligand‐enabled aza‐Heck cyclizations and cascades of N‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidi...

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Detalles Bibliográficos
Autores principales: Hazelden, Ian R., Carmona, Rafaela C., Langer, Thomas, Pringle, Paul G., Bower, John F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969259/
https://www.ncbi.nlm.nih.gov/pubmed/29488677
http://dx.doi.org/10.1002/anie.201801109
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author Hazelden, Ian R.
Carmona, Rafaela C.
Langer, Thomas
Pringle, Paul G.
Bower, John F.
author_facet Hazelden, Ian R.
Carmona, Rafaela C.
Langer, Thomas
Pringle, Paul G.
Bower, John F.
author_sort Hazelden, Ian R.
collection PubMed
description Ligand‐enabled aza‐Heck cyclizations and cascades of N‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines.
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spelling pubmed-59692592018-05-30 Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N‐(Pentafluorobenzoyloxy)carbamates Hazelden, Ian R. Carmona, Rafaela C. Langer, Thomas Pringle, Paul G. Bower, John F. Angew Chem Int Ed Engl Communications Ligand‐enabled aza‐Heck cyclizations and cascades of N‐(pentafluorobenzoyloxy)carbamates are described. These studies encompass the first examples of efficient non‐biased 6‐exo aza‐Heck cyclizations. The methodology provides direct and flexible access to carbamate protected pyrrolidines and piperidines. John Wiley and Sons Inc. 2018-03-22 2018-04-23 /pmc/articles/PMC5969259/ /pubmed/29488677 http://dx.doi.org/10.1002/anie.201801109 Text en © 2018 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Communications
Hazelden, Ian R.
Carmona, Rafaela C.
Langer, Thomas
Pringle, Paul G.
Bower, John F.
Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N‐(Pentafluorobenzoyloxy)carbamates
title Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N‐(Pentafluorobenzoyloxy)carbamates
title_full Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N‐(Pentafluorobenzoyloxy)carbamates
title_fullStr Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N‐(Pentafluorobenzoyloxy)carbamates
title_full_unstemmed Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N‐(Pentafluorobenzoyloxy)carbamates
title_short Pyrrolidines and Piperidines by Ligand‐Enabled Aza‐Heck Cyclizations and Cascades of N‐(Pentafluorobenzoyloxy)carbamates
title_sort pyrrolidines and piperidines by ligand‐enabled aza‐heck cyclizations and cascades of n‐(pentafluorobenzoyloxy)carbamates
topic Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5969259/
https://www.ncbi.nlm.nih.gov/pubmed/29488677
http://dx.doi.org/10.1002/anie.201801109
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