Long-Term Administration of Conjugated Estrogen and Bazedoxifene Decreased Murine Fecal β-Glucuronidase Activity Without Impacting Overall Microbiome Community

Conjugated estrogens (CE) and Bazedoxifene (BZA) combination is used to alleviate menopause-associated symptoms in women. CE+BZA undergo first-pass-metabolism in the liver and deconjugation by gut microbiome via β-glucuronidase (GUS) enzyme inside the distal gut. To date, the impact of long-term exp...

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Detalles Bibliográficos
Autores principales: Chen, Karen Lee Ann, Liu, Xiaoji, Zhao, Yiru Chen, Hieronymi, Kadriye, Rossi, Gianluigi, Auvil, Loretta Sue, Welge, Michael, Bushell, Colleen, Smith, Rebecca Lee, Carlson, Kathryn E., Kim, Sung Hoon, Katzenellenbogen, John A., Miller, Michael Joseph, Madak-Erdogan, Zeynep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970144/
https://www.ncbi.nlm.nih.gov/pubmed/29802368
http://dx.doi.org/10.1038/s41598-018-26506-1

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