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Effects of Low-level Brodifacoum Exposure on the Feline Immune Response

Anticoagulant rodenticides have been implicated as a potential inciting factor in the development of mange in wild felids, but a causative association between anticoagulant rodenticide exposure and immune suppression has not been established. Specific-pathogen-free domestic cats were exposed to brod...

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Autores principales: Kopanke, Jennifer H., Horak, Katherine E., Musselman, Esther, Miller, Craig A., Bennett, Kristine, Olver, Christine S., Volker, Steven F., VandeWoude, Sue, Bevins, Sarah N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970145/
https://www.ncbi.nlm.nih.gov/pubmed/29802369
http://dx.doi.org/10.1038/s41598-018-26558-3
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author Kopanke, Jennifer H.
Horak, Katherine E.
Musselman, Esther
Miller, Craig A.
Bennett, Kristine
Olver, Christine S.
Volker, Steven F.
VandeWoude, Sue
Bevins, Sarah N.
author_facet Kopanke, Jennifer H.
Horak, Katherine E.
Musselman, Esther
Miller, Craig A.
Bennett, Kristine
Olver, Christine S.
Volker, Steven F.
VandeWoude, Sue
Bevins, Sarah N.
author_sort Kopanke, Jennifer H.
collection PubMed
description Anticoagulant rodenticides have been implicated as a potential inciting factor in the development of mange in wild felids, but a causative association between anticoagulant rodenticide exposure and immune suppression has not been established. Specific-pathogen-free domestic cats were exposed to brodifacoum over a 6-week period to determine whether chronic, low-level exposure altered the feline immune response. Cats were vaccinated with irrelevant antigens at different points during the course of the experiment to assess recall and direct immune responses. Measures of immune response included delayed-type hypersensitivity tests and cell proliferation assays. IgE and antigen-specific antibodies were quantified via ELISA assays, and cytokine induction following exposure to vaccine antigens was also analyzed. While cats had marked levels of brodifacoum present in blood during the study, no cats developed coagulopathies or hematologic abnormalities. Brodifacoum-exposed cats had transient, statistically significant decreases in the production of certain cytokines, but all other measures of immune function remained unaffected throughout the study period. This study indicates that cats may be more resistant to clinical effects of brodifacoum exposure than other species and suggests that the gross impacts of environmentally realistic brodifacoum exposure on humoral and cell-mediated immunity against foreign antigen exposures in domestic cats are minimal.
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spelling pubmed-59701452018-05-30 Effects of Low-level Brodifacoum Exposure on the Feline Immune Response Kopanke, Jennifer H. Horak, Katherine E. Musselman, Esther Miller, Craig A. Bennett, Kristine Olver, Christine S. Volker, Steven F. VandeWoude, Sue Bevins, Sarah N. Sci Rep Article Anticoagulant rodenticides have been implicated as a potential inciting factor in the development of mange in wild felids, but a causative association between anticoagulant rodenticide exposure and immune suppression has not been established. Specific-pathogen-free domestic cats were exposed to brodifacoum over a 6-week period to determine whether chronic, low-level exposure altered the feline immune response. Cats were vaccinated with irrelevant antigens at different points during the course of the experiment to assess recall and direct immune responses. Measures of immune response included delayed-type hypersensitivity tests and cell proliferation assays. IgE and antigen-specific antibodies were quantified via ELISA assays, and cytokine induction following exposure to vaccine antigens was also analyzed. While cats had marked levels of brodifacoum present in blood during the study, no cats developed coagulopathies or hematologic abnormalities. Brodifacoum-exposed cats had transient, statistically significant decreases in the production of certain cytokines, but all other measures of immune function remained unaffected throughout the study period. This study indicates that cats may be more resistant to clinical effects of brodifacoum exposure than other species and suggests that the gross impacts of environmentally realistic brodifacoum exposure on humoral and cell-mediated immunity against foreign antigen exposures in domestic cats are minimal. Nature Publishing Group UK 2018-05-25 /pmc/articles/PMC5970145/ /pubmed/29802369 http://dx.doi.org/10.1038/s41598-018-26558-3 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Kopanke, Jennifer H.
Horak, Katherine E.
Musselman, Esther
Miller, Craig A.
Bennett, Kristine
Olver, Christine S.
Volker, Steven F.
VandeWoude, Sue
Bevins, Sarah N.
Effects of Low-level Brodifacoum Exposure on the Feline Immune Response
title Effects of Low-level Brodifacoum Exposure on the Feline Immune Response
title_full Effects of Low-level Brodifacoum Exposure on the Feline Immune Response
title_fullStr Effects of Low-level Brodifacoum Exposure on the Feline Immune Response
title_full_unstemmed Effects of Low-level Brodifacoum Exposure on the Feline Immune Response
title_short Effects of Low-level Brodifacoum Exposure on the Feline Immune Response
title_sort effects of low-level brodifacoum exposure on the feline immune response
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970145/
https://www.ncbi.nlm.nih.gov/pubmed/29802369
http://dx.doi.org/10.1038/s41598-018-26558-3
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