Identification of a unique Ca(2+)-binding site in rat acid-sensing ion channel 3

Acid-sensing ion channels (ASICs) evolved to sense changes in extracellular acidity with the divalent cation calcium (Ca(2+)) as an allosteric modulator and channel blocker. The channel-blocking activity is most apparent in ASIC3, as removing Ca(2+) results in channel opening, with the site’s locati...

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Detalles Bibliográficos
Autores principales: Zuo, Zhicheng, Smith, Rachel N., Chen, Zhenglan, Agharkar, Amruta S., Snell, Heather D., Huang, Renqi, Liu, Jin, Gonzales, Eric B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970173/
https://www.ncbi.nlm.nih.gov/pubmed/29802295
http://dx.doi.org/10.1038/s41467-018-04424-0

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