Natural compound Oblongifolin C confers gemcitabine resistance in pancreatic cancer by downregulating Src/MAPK/ERK pathways

Gemcitabine (GEM)-induced drug resistance is the major reason for the failure of chemotherapy in pancreatic cancer (PC). In this study, we found that Oblongifolin C (OC) efficiently inhibited PC cell proliferation by inducing G0/G1 arrest and apoptosis. Also, our mechanism study demonstrated that OC...

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Detalles Bibliográficos
Autores principales: Li, Yang, Xi, Zhichao, Chen, Xiaoqiong, Cai, Shuangfan, Liang, Chen, Wang, Zhen, Li, Yingyi, Tan, Hongsheng, Lao, Yuanzhi, Xu, Hongxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970202/
https://www.ncbi.nlm.nih.gov/pubmed/29749405
http://dx.doi.org/10.1038/s41419-018-0574-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970202/
https://www.ncbi.nlm.nih.gov/pubmed/29749405
http://dx.doi.org/10.1038/s41419-018-0574-1

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