Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation

Over 80% of diffuse intrinsic pontine gliomas (DIPGs) harbor a point mutation in histone H3.3 where lysine 27 is substituted with methionine (H3.3K27M); however, how the mutation affects kinetics and function of PcG proteins remains elusive. We demonstrate that H3.3K27M prolongs the residence time a...

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Detalles Bibliográficos
Autores principales: Tatavosian, Roubina, Duc, Huy Nguyen, Huynh, Thao Ngoc, Fang, Dong, Schmitt, Benjamin, Shi, Xiaodong, Deng, Yiming, Phiel, Christopher, Yao, Tingting, Zhang, Zhiguo, Wang, Haobin, Ren, Xiaojun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970213/
https://www.ncbi.nlm.nih.gov/pubmed/29802243
http://dx.doi.org/10.1038/s41467-018-04455-7

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