Obeticholic acid protects against hepatocyte death and liver fibrosis in a murine model of nonalcoholic steatohepatitis

Accumulating evidence has suggested that farnesoid X receptor (FXR) agonists, such as obeticholic acid (OCA) are therapeutically useful for non-alcoholic steatohepatitis (NASH). However, it is still unclear how FXR agonists protect against NASH and which cell type is the main target of FXR agonists....

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Detalles Bibliográficos
Autores principales: Goto, Toshihiro, Itoh, Michiko, Suganami, Takayoshi, Kanai, Sayaka, Shirakawa, Ibuki, Sakai, Takeru, Asakawa, Masahiro, Yoneyama, Toshihiro, Kai, Toshihiro, Ogawa, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970222/
https://www.ncbi.nlm.nih.gov/pubmed/29802399
http://dx.doi.org/10.1038/s41598-018-26383-8

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