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Altered plasma arginine metabolome precedes behavioural and brain arginine metabolomic profile changes in the APPswe/PS1ΔE9 mouse model of Alzheimer’s disease

While amyloid-beta (Aβ) peptides play a central role in the development of Alzheimer’s disease (AD), recent evidence also implicates altered metabolism of L-arginine in the pathogenesis of AD. The present study systematically investigated how behavioural function and the brain and plasma arginine me...

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Detalles Bibliográficos
Autores principales:	Bergin, DH, Jing, Y, Mockett, BG, Zhang, H, Abraham, WC, Liu, P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970225/ https://www.ncbi.nlm.nih.gov/pubmed/29802260 http://dx.doi.org/10.1038/s41398-018-0149-z

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