TDP-43 induces p53-mediated cell death of cortical progenitors and immature neurons

TAR DNA-binding protein 43 (TDP-43) is a key player in neurodegenerative diseases including frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). Accumulation of TDP-43 is associated with neuronal death in the brain. How increased and disease-causing mutant forms of TDP-4...

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Detalles Bibliográficos
Autores principales: Vogt, Miriam A., Ehsaei, Zahra, Knuckles, Philip, Higginbottom, Adrian, Helmbrecht, Michaela S., Kunath, Tilo, Eggan, Kevin, Williams, Luis A., Shaw, Pamela J., Wurst, Wolfgang, Floss, Thomas, Huber, Andrea B., Taylor, Verdon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970242/
https://www.ncbi.nlm.nih.gov/pubmed/29802307
http://dx.doi.org/10.1038/s41598-018-26397-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970242/
https://www.ncbi.nlm.nih.gov/pubmed/29802307
http://dx.doi.org/10.1038/s41598-018-26397-2

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