Testosterone is an endogenous regulator of BAFF and splenic B cell number

Testosterone deficiency in men is associated with increased risk for autoimmunity and increased B cell numbers through unknown mechanisms. Here we show that testosterone regulates the cytokine BAFF, an essential survival factor for B cells. Male mice lacking the androgen receptor have increased sple...

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Detalles Bibliográficos
Autores principales: Wilhelmson, Anna S., Lantero Rodriguez, Marta, Stubelius, Alexandra, Fogelstrand, Per, Johansson, Inger, Buechler, Matthew B., Lianoglou, Steve, Kapoor, Varun N., Johansson, Maria E., Fagman, Johan B., Duhlin, Amanda, Tripathi, Prabhanshu, Camponeschi, Alessandro, Porse, Bo T., Rolink, Antonius G., Nissbrandt, Hans, Turley, Shannon J., Carlsten, Hans, Mårtensson, Inga-Lill, Karlsson, Mikael C. I., Tivesten, Åsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970247/
https://www.ncbi.nlm.nih.gov/pubmed/29802242
http://dx.doi.org/10.1038/s41467-018-04408-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970247/
https://www.ncbi.nlm.nih.gov/pubmed/29802242
http://dx.doi.org/10.1038/s41467-018-04408-0

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