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Complex Hydrogels Composed of Chitosan with Ring-opened Polyvinyl Pyrrolidone as a Gastroretentive Drug Dosage Form to Enhance the Bioavailability of Bisphosphonates
Complex hydrogels formed with chitosan (CS) and ring-opened polyvinyl pyrrolidone (roPVP) as a swellable mucoadhesive gastroretentive drug dosage form (smGRDDF) were prepared and characterized. CS/roPVP hydrogels were produced by blending CS with roPVP obtained by basic treatment of PVP. Effects of...
Autores principales: | Su, Chia-Yu, Ho, Hsiu-O, Chen, Ying-Chen, Yu, Yu-Ting, Liu, Der-Zen, Chao, Fang-Ching, Sheu, Ming-Thau |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970250/ https://www.ncbi.nlm.nih.gov/pubmed/29802291 http://dx.doi.org/10.1038/s41598-018-26432-2 |
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