Immunotherapy in Breast Cancer: the New Frontier

PURPOSE OF REVIEW: This review summarizes current immunotherapies in breast cancer, with an emphasis on immune checkpoint inhibitors and vaccines. RECENT FINDINGS: Combination immunotherapy with checkpoint inhibitors and cytotoxic therapies have shown promising results. Active clinical trials are on...

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Detalles Bibliográficos
Autores principales: Hu, Zishuo I., McArthur, Heather L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2018
Materias:
Translational Research (RL Aft, Section Editor)
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970253/
https://www.ncbi.nlm.nih.gov/pubmed/29881518
http://dx.doi.org/10.1007/s12609-018-0274-y
Descripción
Sumario:PURPOSE OF REVIEW: This review summarizes current immunotherapies in breast cancer, with an emphasis on immune checkpoint inhibitors and vaccines. RECENT FINDINGS: Combination immunotherapy with checkpoint inhibitors and cytotoxic therapies have shown promising results. Active clinical trials are ongoing in both early stage and metastatic settings for triple negative, HER2+, and hormone-positive breast cancer patients. SUMMARY: Ongoing challenges remain in defining biomarkers that predict response to immunotherapy, determining the optimal combination immunotherapies, and enhancing the immunogenicity of breast cancer subtypes.

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