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Metabolic disorders during pregnancy and postpartum cardiometabolic risk
Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinica...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bioscientifica Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970277/ https://www.ncbi.nlm.nih.gov/pubmed/29712720 http://dx.doi.org/10.1530/EC-18-0130 |
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author | Patti, Angelo Maria Pafili, Kalliopi Papanas, Nikolaos Rizzo, Manfredi |
author_facet | Patti, Angelo Maria Pafili, Kalliopi Papanas, Nikolaos Rizzo, Manfredi |
author_sort | Patti, Angelo Maria |
collection | PubMed |
description | Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinically evident cardiovascular (CV) events. Insulin resistance and central adiposity are of crucial importance in the development of metabolic syndrome, and they appear to correlate with CV risk factors, including hypertension and atherogenic dyslipidaemia. Hypertensive disease of pregnancy (HDP) is more likely to be an accompanying co-morbidity in pregnancies complicated with GDM. There is still inconsistent evidence as to whether or not co-existent GDM and HDP have a synergistic effects on postpartum risk of cardiometabolic disease; however, this synergism is becoming more accepted since both these conditions may promote endothelial inflammation and early atherosclerosis. Regardless of the presence or absence of the synergism between GDM and HDP, these conditions need to be dealt early enough, in order to reduce CV morbidity and to improve health outcomes for both women and their offspring. |
format | Online Article Text |
id | pubmed-5970277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Bioscientifica Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-59702772018-05-30 Metabolic disorders during pregnancy and postpartum cardiometabolic risk Patti, Angelo Maria Pafili, Kalliopi Papanas, Nikolaos Rizzo, Manfredi Endocr Connect Editorial Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinically evident cardiovascular (CV) events. Insulin resistance and central adiposity are of crucial importance in the development of metabolic syndrome, and they appear to correlate with CV risk factors, including hypertension and atherogenic dyslipidaemia. Hypertensive disease of pregnancy (HDP) is more likely to be an accompanying co-morbidity in pregnancies complicated with GDM. There is still inconsistent evidence as to whether or not co-existent GDM and HDP have a synergistic effects on postpartum risk of cardiometabolic disease; however, this synergism is becoming more accepted since both these conditions may promote endothelial inflammation and early atherosclerosis. Regardless of the presence or absence of the synergism between GDM and HDP, these conditions need to be dealt early enough, in order to reduce CV morbidity and to improve health outcomes for both women and their offspring. Bioscientifica Ltd 2018-04-30 /pmc/articles/PMC5970277/ /pubmed/29712720 http://dx.doi.org/10.1530/EC-18-0130 Text en © 2018 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) . |
spellingShingle | Editorial Patti, Angelo Maria Pafili, Kalliopi Papanas, Nikolaos Rizzo, Manfredi Metabolic disorders during pregnancy and postpartum cardiometabolic risk |
title | Metabolic disorders during pregnancy and postpartum cardiometabolic risk |
title_full | Metabolic disorders during pregnancy and postpartum cardiometabolic risk |
title_fullStr | Metabolic disorders during pregnancy and postpartum cardiometabolic risk |
title_full_unstemmed | Metabolic disorders during pregnancy and postpartum cardiometabolic risk |
title_short | Metabolic disorders during pregnancy and postpartum cardiometabolic risk |
title_sort | metabolic disorders during pregnancy and postpartum cardiometabolic risk |
topic | Editorial |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970277/ https://www.ncbi.nlm.nih.gov/pubmed/29712720 http://dx.doi.org/10.1530/EC-18-0130 |
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