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Metabolic disorders during pregnancy and postpartum cardiometabolic risk

Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinica...

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Autores principales: Patti, Angelo Maria, Pafili, Kalliopi, Papanas, Nikolaos, Rizzo, Manfredi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970277/
https://www.ncbi.nlm.nih.gov/pubmed/29712720
http://dx.doi.org/10.1530/EC-18-0130
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author Patti, Angelo Maria
Pafili, Kalliopi
Papanas, Nikolaos
Rizzo, Manfredi
author_facet Patti, Angelo Maria
Pafili, Kalliopi
Papanas, Nikolaos
Rizzo, Manfredi
author_sort Patti, Angelo Maria
collection PubMed
description Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinically evident cardiovascular (CV) events. Insulin resistance and central adiposity are of crucial importance in the development of metabolic syndrome, and they appear to correlate with CV risk factors, including hypertension and atherogenic dyslipidaemia. Hypertensive disease of pregnancy (HDP) is more likely to be an accompanying co-morbidity in pregnancies complicated with GDM. There is still inconsistent evidence as to whether or not co-existent GDM and HDP have a synergistic effects on postpartum risk of cardiometabolic disease; however, this synergism is becoming more accepted since both these conditions may promote endothelial inflammation and early atherosclerosis. Regardless of the presence or absence of the synergism between GDM and HDP, these conditions need to be dealt early enough, in order to reduce CV morbidity and to improve health outcomes for both women and their offspring.
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spelling pubmed-59702772018-05-30 Metabolic disorders during pregnancy and postpartum cardiometabolic risk Patti, Angelo Maria Pafili, Kalliopi Papanas, Nikolaos Rizzo, Manfredi Endocr Connect Editorial Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinically evident cardiovascular (CV) events. Insulin resistance and central adiposity are of crucial importance in the development of metabolic syndrome, and they appear to correlate with CV risk factors, including hypertension and atherogenic dyslipidaemia. Hypertensive disease of pregnancy (HDP) is more likely to be an accompanying co-morbidity in pregnancies complicated with GDM. There is still inconsistent evidence as to whether or not co-existent GDM and HDP have a synergistic effects on postpartum risk of cardiometabolic disease; however, this synergism is becoming more accepted since both these conditions may promote endothelial inflammation and early atherosclerosis. Regardless of the presence or absence of the synergism between GDM and HDP, these conditions need to be dealt early enough, in order to reduce CV morbidity and to improve health outcomes for both women and their offspring. Bioscientifica Ltd 2018-04-30 /pmc/articles/PMC5970277/ /pubmed/29712720 http://dx.doi.org/10.1530/EC-18-0130 Text en © 2018 The authors http://creativecommons.org/licenses/by-nc/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Editorial
Patti, Angelo Maria
Pafili, Kalliopi
Papanas, Nikolaos
Rizzo, Manfredi
Metabolic disorders during pregnancy and postpartum cardiometabolic risk
title Metabolic disorders during pregnancy and postpartum cardiometabolic risk
title_full Metabolic disorders during pregnancy and postpartum cardiometabolic risk
title_fullStr Metabolic disorders during pregnancy and postpartum cardiometabolic risk
title_full_unstemmed Metabolic disorders during pregnancy and postpartum cardiometabolic risk
title_short Metabolic disorders during pregnancy and postpartum cardiometabolic risk
title_sort metabolic disorders during pregnancy and postpartum cardiometabolic risk
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970277/
https://www.ncbi.nlm.nih.gov/pubmed/29712720
http://dx.doi.org/10.1530/EC-18-0130
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