Cargando…

Patient-derived multicellular tumor spheroids towards optimized treatment for patients with hepatocellular carcinoma

BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide and has poor prognosis. Specially, patients with HCC usually have poor tolerance of systemic chemotherapy, because HCCs develop from chronically damaged tissue that contains considerable inflammation, fib...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Yeonhwa, Kim, Jin-Sun, Kim, Se-Hyuk, Park, Yoon Kyung, Yu, Eunsil, Kim, Ki-Hun, Seo, Eul-Ju, Oh, Heung-Bum, Lee, Han Chu, Kim, Kang Mo, Seo, Haeng Ran
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5970513/ https://www.ncbi.nlm.nih.gov/pubmed/29801504 http://dx.doi.org/10.1186/s13046-018-0752-0

Ejemplares similares

Activated hepatic stellate cells play pivotal roles in hepatocellular carcinoma cell chemoresistance and migration in multicellular tumor spheroids
por: Song, Yeonhwa, et al.
Publicado: (2016)

Inhibitors of Na(+)/K(+) ATPase exhibit antitumor effects on multicellular tumor spheroids of hepatocellular carcinoma
por: Song, Yeonhwa, et al.
Publicado: (2020)

GSK-3β regulates the endothelial-to-mesenchymal transition via reciprocal crosstalk between NSCLC cells and HUVECs in multicellular tumor spheroid models
por: Kim, Se-Hyuk, et al.
Publicado: (2019)

Identification of hepatic fibrosis inhibitors through morphometry analysis of a hepatic multicellular spheroids model
por: Song, Yeonhwa, et al.
Publicado: (2021)

Deciphering the underlying mechanism of liver diseases through utilization of multicellular hepatic spheroid models
por: Kim, Sanghwa, et al.
Publicado: (2023)

Anti-Cancer Effects of YAP Inhibitor (CA3) in Combination with Sorafenib against Hepatocellular Carcinoma (HCC) in Patient-Derived Multicellular Tumor Spheroid Models (MCTS)
por: Han, Sojung, et al.
Publicado: (2022)

Expression of HYOU1 via Reciprocal Crosstalk between NSCLC Cells and HUVECs Control Cancer Progression and Chemoresistance in Tumor Spheroids
por: Lee, Minji, et al.
Publicado: (2021)

Challenges of applying multicellular tumor spheroids in preclinical phase
por: Han, Se Jik, et al.
Publicado: (2021)

Oxytetracycline have the therapeutic efficiency in CD133(+) HCC population through suppression CD133 expression by decreasing of protein stability of CD133
por: Song, Yeonhwa, et al.
Publicado: (2018)

TGF-β–independent CTGF induction regulates cell adhesion mediated drug resistance by increasing collagen I in HCC
por: Song, Yeonhwa, et al.
Publicado: (2017)

Generation of uniform-sized multicellular tumor spheroids using hydrogel microwells for advanced drug screening
por: Lee, Jong Min, et al.
Publicado: (2018)

Recent Advances in Multicellular Tumor Spheroid Generation for Drug Screening
por: Lee, Kwang-Ho, et al.
Publicado: (2021)

Sulfasalazine attenuates evading anticancer response of CD133-positive hepatocellular carcinoma cells
por: Song, Yeonhwa, et al.
Publicado: (2017)

Unsuccessful mitosis in multicellular tumour spheroids
por: Molla, Annie, et al.
Publicado: (2017)

HO-1089 and HO-1197, Novel Herbal Formulas, Have Antitumor Effects via Suppression of PLK1 (Polo-like Kinase 1) Expression in Hepatocellular Carcinoma
por: Song, Yeonhwa, et al.
Publicado: (2023)

Argininosuccinate synthase 1 suppresses tumor progression through activation of PERK/eIF2α/ATF4/CHOP axis in hepatocellular carcinoma
por: Kim, Sanghwa, et al.
Publicado: (2021)

Chromenopyrimidinone Controls Stemness and Malignancy by suppressing CD133 Expression in Hepatocellular Carcinoma
por: Song, Yeonhwa, et al.
Publicado: (2020)

3D Multicellular Tumor Spheroids in a Microfluidic Droplet System for Investigation of Drug Resistance
por: Lee, Sang Ik, et al.
Publicado: (2022)

Tunable hybrid hydrogels with multicellular spheroids for modeling desmoplastic pancreatic cancer
por: Ermis, Menekse, et al.
Publicado: (2023)

Identification of radiation‐induced EndMT inhibitors through cell‐based phenomic screening
por: Song, Yeonhwa, et al.
Publicado: (2018)

Resistance to vincristine of human cells grown as multicellular spheroids.
por: Wibe, E.
Publicado: (1980)

Increased nanoparticle penetration in collagenase-treated multicellular spheroids
por: Goodman, Thomas T, et al.
Publicado: (2007)

Natural and Synthetic Biomaterials for Engineering Multicellular Tumor Spheroids
por: Kamatar, Advika, et al.
Publicado: (2020)

Multicellular Tumor Spheroids in Nanomedicine Research: A Perspective
por: Rossi, Martina, et al.
Publicado: (2022)

Protocol for generation of multicellular spheroids through reduced gravity
por: Zinn, Dylan A., et al.
Publicado: (2023)

Single Spheroid Metabolomics: Optimizing Sample Preparation of Three-Dimensional Multicellular Tumor Spheroids
por: Rusz, Mate, et al.
Publicado: (2019)

Hepatocellular carcinoma-targeted drug discovery through image-based phenotypic screening in co-cultures of HCC cells with hepatocytes
por: Jang, Jae-Woo, et al.
Publicado: (2016)

Cyclooxygenase-2 inhibitor is a robust enhancer of anticancer agents against hepatocellular carcinoma multicellular spheroids
por: Cui, Jie, et al.
Publicado: (2014)

Influence of glucose and oxygen supply conditions on the oxygenation of multicellular spheroids.
por: Mueller-Klieser, W., et al.
Publicado: (1986)

Multicellular Self-Assembled Spheroidal Model of the Blood Brain Barrier
por: Urich, Eduard, et al.
Publicado: (2013)

Study of the Chemotactic Response of Multicellular Spheroids in a Microfluidic Device
por: Ayuso, Jose M., et al.
Publicado: (2015)

Linking hypoxia, DNA damage and proliferation in multicellular tumor spheroids
por: Riffle, Stephen, et al.
Publicado: (2017)

Modeling tumor cell adaptations to hypoxia in multicellular tumor spheroids
por: Riffle, Stephen, et al.
Publicado: (2017)

Radiosensitivity of quiescent and proliferating cells grown as multicellular tumor spheroids
por: Onozato, Yusuke, et al.
Publicado: (2017)

Heterotypic Multicellular Spheroids as Experimental and Preclinical Models of Sprouting Angiogenesis
por: Vakhrushev, Igor V., et al.
Publicado: (2021)

Applications and Advances of Multicellular Tumor Spheroids: Challenges in Their Development and Analysis
por: Mitrakas, Achilleas G., et al.
Publicado: (2023)

Synergistic antitumor activity of sorafenib and MG149 in hepatocellular carcinoma cells
por: Moon, Byul, et al.
Publicado: (2022)

Generation of multicellular tumor spheroids with micro-well array for anticancer drug combination screening based on a valuable biomarker of hepatocellular carcinoma
por: Wang, Qi, et al.
Publicado: (2022)

FAX-RIC enables robust profiling of dynamic RNP complex formation in multicellular organisms in vivo
por: Na, Yongwoo, et al.
Publicado: (2020)

Response of EMT6 multicellular tumour spheroids to hyperthermia and cytotoxic drugs.
por: Morgan, J. E., et al.
Publicado: (1981)

Cannot write session to /tmp/vufind_sessions/sess_uibvnfmocg9302p5vepe013n87