Irpexoates A–D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus

ABSTRACT: Four eburicane-type triterpenoids with malonyl modifications, namely irpexoates A–D (1–4), were isolated from the fruiting bodies of the medicinal fungus Irpex lacteus. The structures of the new compounds were established by extensive spectroscopic methods, including 1D and 2D NMR, HRESIMS...

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Autores principales: Tang, Yang, Zhao, Zhen-Zhu, Li, Zheng-Hui, Feng, Tao, Chen, He-Ping, Liu, Ji-Kai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971031/
https://www.ncbi.nlm.nih.gov/pubmed/29594954
http://dx.doi.org/10.1007/s13659-018-0160-3
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author Tang, Yang
Zhao, Zhen-Zhu
Li, Zheng-Hui
Feng, Tao
Chen, He-Ping
Liu, Ji-Kai
author_facet Tang, Yang
Zhao, Zhen-Zhu
Li, Zheng-Hui
Feng, Tao
Chen, He-Ping
Liu, Ji-Kai
author_sort Tang, Yang
collection PubMed
description ABSTRACT: Four eburicane-type triterpenoids with malonyl modifications, namely irpexoates A–D (1–4), were isolated from the fruiting bodies of the medicinal fungus Irpex lacteus. The structures of the new compounds were established by extensive spectroscopic methods, including 1D and 2D NMR, HRESIMS spectroscopic analysis. Irpexoate B (2) displayed weak cytotoxicity against four human cancer cell lines (A-549, SMMC-7721, MCF-7, SW480) with IC(50) values varying from 22.9 to 34.0 μM, and irpexoate D (4) showed weak cytotoxicity against the human cancer cell line SW480 with an IC(50) value of 35.2 μM. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-018-0160-3) contains supplementary material, which is available to authorized users.
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spelling pubmed-59710312018-06-05 Irpexoates A–D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus Tang, Yang Zhao, Zhen-Zhu Li, Zheng-Hui Feng, Tao Chen, He-Ping Liu, Ji-Kai Nat Prod Bioprospect Original Article ABSTRACT: Four eburicane-type triterpenoids with malonyl modifications, namely irpexoates A–D (1–4), were isolated from the fruiting bodies of the medicinal fungus Irpex lacteus. The structures of the new compounds were established by extensive spectroscopic methods, including 1D and 2D NMR, HRESIMS spectroscopic analysis. Irpexoate B (2) displayed weak cytotoxicity against four human cancer cell lines (A-549, SMMC-7721, MCF-7, SW480) with IC(50) values varying from 22.9 to 34.0 μM, and irpexoate D (4) showed weak cytotoxicity against the human cancer cell line SW480 with an IC(50) value of 35.2 μM. GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-018-0160-3) contains supplementary material, which is available to authorized users. Springer Singapore 2018-03-28 /pmc/articles/PMC5971031/ /pubmed/29594954 http://dx.doi.org/10.1007/s13659-018-0160-3 Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Tang, Yang
Zhao, Zhen-Zhu
Li, Zheng-Hui
Feng, Tao
Chen, He-Ping
Liu, Ji-Kai
Irpexoates A–D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus
title Irpexoates A–D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus
title_full Irpexoates A–D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus
title_fullStr Irpexoates A–D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus
title_full_unstemmed Irpexoates A–D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus
title_short Irpexoates A–D, Four Triterpenoids with Malonyl Modifications from the Fruiting Bodies of the Medicinal Fungus Irpex lacteus
title_sort irpexoates a–d, four triterpenoids with malonyl modifications from the fruiting bodies of the medicinal fungus irpex lacteus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971031/
https://www.ncbi.nlm.nih.gov/pubmed/29594954
http://dx.doi.org/10.1007/s13659-018-0160-3
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