Three New Indole Alkaloids from Tabernaemontana divaricata

ABSTRACT: Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids w...

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Detalles Bibliográficos
Autores principales: Deng, Yan, Bao, Mei-Fen, Shi, Bao-Bao, Wu, Jing, Cai, Xiang-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971036/
https://www.ncbi.nlm.nih.gov/pubmed/29754315
http://dx.doi.org/10.1007/s13659-018-0166-x
Descripción
Sumario:ABSTRACT: Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids were determined by spectroscopic analyses. All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer, HeLa, and A-549 lung cancer cell lines (IC(50) > 20 µM). GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-018-0166-x) contains supplementary material, which is available to authorized users.

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