Three New Indole Alkaloids from Tabernaemontana divaricata

ABSTRACT: Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids w...

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Detalles Bibliográficos
Autores principales: Deng, Yan, Bao, Mei-Fen, Shi, Bao-Bao, Wu, Jing, Cai, Xiang-Hai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2018
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971036/
https://www.ncbi.nlm.nih.gov/pubmed/29754315
http://dx.doi.org/10.1007/s13659-018-0166-x
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author Deng, Yan
Bao, Mei-Fen
Shi, Bao-Bao
Wu, Jing
Cai, Xiang-Hai
author_facet Deng, Yan
Bao, Mei-Fen
Shi, Bao-Bao
Wu, Jing
Cai, Xiang-Hai
author_sort Deng, Yan
collection PubMed
description ABSTRACT: Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids were determined by spectroscopic analyses. All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer, HeLa, and A-549 lung cancer cell lines (IC(50) > 20 µM). GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-018-0166-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-59710362018-06-05 Three New Indole Alkaloids from Tabernaemontana divaricata Deng, Yan Bao, Mei-Fen Shi, Bao-Bao Wu, Jing Cai, Xiang-Hai Nat Prod Bioprospect Original Article ABSTRACT: Three new monoterpene indole alkaloids, 3α-hydroxymethyl-ibogamine (1), 3α-acetatemethoxyl-ibogamine (2), 16α-hydroxyl-ibogamine (3) together with six known alkaloids were isolated from the branches and leaves of Tabernaemontana divaricata (Apocynaceae). The structures of these alkaloids were determined by spectroscopic analyses. All isolated compounds showed no significant cytotoxicity against SGC-7901 gastric cancer, HeLa, and A-549 lung cancer cell lines (IC(50) > 20 µM). GRAPHICAL ABSTRACT: [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13659-018-0166-x) contains supplementary material, which is available to authorized users. Springer Singapore 2018-05-12 /pmc/articles/PMC5971036/ /pubmed/29754315 http://dx.doi.org/10.1007/s13659-018-0166-x Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Original Article
Deng, Yan
Bao, Mei-Fen
Shi, Bao-Bao
Wu, Jing
Cai, Xiang-Hai
Three New Indole Alkaloids from Tabernaemontana divaricata
title Three New Indole Alkaloids from Tabernaemontana divaricata
title_full Three New Indole Alkaloids from Tabernaemontana divaricata
title_fullStr Three New Indole Alkaloids from Tabernaemontana divaricata
title_full_unstemmed Three New Indole Alkaloids from Tabernaemontana divaricata
title_short Three New Indole Alkaloids from Tabernaemontana divaricata
title_sort three new indole alkaloids from tabernaemontana divaricata
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971036/
https://www.ncbi.nlm.nih.gov/pubmed/29754315
http://dx.doi.org/10.1007/s13659-018-0166-x
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