TRAF6 Mediates Basal Activation of NF-κB Necessary for Hematopoietic Stem Cell Homeostasis

Basal nuclear factor κB (NF-κB) activation is required for hematopoietic stem cell (HSC) homeostasis in the absence of inflammation; however, the upstream mediators of basal NF-κB signaling are less well understood. Here, we describe TRAF6 as an essential regulator of HSC homeostasis through basal a...

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Detalles Bibliográficos
Autores principales: Fang, Jing, Muto, Tomoya, Kleppe, Maria, Bolanos, Lyndsey C., Hueneman, Kathleen M., Walker, Callum S., Sampson, Leesa, Wellendorf, Ashley M., Chetal, Kashish, Choi, Kwangmin, Salomonis, Nathan, Choi, Yongwon, Zheng, Yi, Cancelas, Jose A., Levine, Ross L., Starczynowski, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971064/
https://www.ncbi.nlm.nih.gov/pubmed/29386112
http://dx.doi.org/10.1016/j.celrep.2018.01.013

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