A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation

Huntington’s disease is caused by an abnormally long polyglutamine tract in the huntingtin protein. This leads to the generation and deposition of N-terminal exon1 fragments of the protein in intracellular aggregates. We combined electron tomography and quantitative fluorescence microscopy to analyz...

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Detalles Bibliográficos
Autores principales: Peskett, Thomas R., Rau, Frédérique, O’Driscoll, Jonathan, Patani, Rickie, Lowe, Alan R., Saibil, Helen R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971205/
https://www.ncbi.nlm.nih.gov/pubmed/29754822
http://dx.doi.org/10.1016/j.molcel.2018.04.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971205/
https://www.ncbi.nlm.nih.gov/pubmed/29754822
http://dx.doi.org/10.1016/j.molcel.2018.04.007

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