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Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience
AIM: To characterize isolated non-obstructive sinusoidal dilatation (SD) by identifying associated conditions, laboratory findings, and histological patterns. METHODS: Retrospectively reviewed 491 patients with SD between 1995 and 2015. Patients with obstruction at the level of the small/large hepat...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Baishideng Publishing Group Inc
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971228/ https://www.ncbi.nlm.nih.gov/pubmed/29844855 http://dx.doi.org/10.4254/wjh.v10.i5.417 |
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author | Sunjaya, Dharma Budi Ramos, Guilherme Piovezani Braga Neto, Manuel Bonfim Lennon, Ryan Mounajjed, Taofic Shah, Vijay Kamath, Patrick Sequeira Simonetto, Douglas Alano |
author_facet | Sunjaya, Dharma Budi Ramos, Guilherme Piovezani Braga Neto, Manuel Bonfim Lennon, Ryan Mounajjed, Taofic Shah, Vijay Kamath, Patrick Sequeira Simonetto, Douglas Alano |
author_sort | Sunjaya, Dharma Budi |
collection | PubMed |
description | AIM: To characterize isolated non-obstructive sinusoidal dilatation (SD) by identifying associated conditions, laboratory findings, and histological patterns. METHODS: Retrospectively reviewed 491 patients with SD between 1995 and 2015. Patients with obstruction at the level of the small/large hepatic veins, portal veins, or right-sided heart failure were excluded along with history of cirrhosis, hepatic malignancy, liver transplant, or absence of electrocardiogram/cardiac echocardiogram. Liver histology was reviewed for extent of SD, fibrosis, red blood cell extravasation, nodular regenerative hyperplasia, hepatic peliosis, and hepatocellular plate atrophy (HPA). RESULTS: We identified 88 patients with non-obstructive SD. Inflammatory conditions (32%) were the most common cause. The most common pattern of liver abnormalities was cholestatic (76%). Majority (78%) had localized SD to Zone III. Medication-related SD had higher proportion of portal hypertension (53%), ascites (58%), and median AST (113 U/L) and ALT (90 U/L) levels. Nineteen patients in our study died within one-year after diagnosis of SD, majority from complications related to underlying diseases. CONCLUSION: Significant proportion of SD and HPA exist without impaired hepatic venous outflow. Isolated SD on liver biopsy, in the absence of congestive hepatopathy, requires further evaluation and portal hypertension should be rule out. |
format | Online Article Text |
id | pubmed-5971228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Baishideng Publishing Group Inc |
record_format | MEDLINE/PubMed |
spelling | pubmed-59712282018-05-29 Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience Sunjaya, Dharma Budi Ramos, Guilherme Piovezani Braga Neto, Manuel Bonfim Lennon, Ryan Mounajjed, Taofic Shah, Vijay Kamath, Patrick Sequeira Simonetto, Douglas Alano World J Hepatol Retrospective Study AIM: To characterize isolated non-obstructive sinusoidal dilatation (SD) by identifying associated conditions, laboratory findings, and histological patterns. METHODS: Retrospectively reviewed 491 patients with SD between 1995 and 2015. Patients with obstruction at the level of the small/large hepatic veins, portal veins, or right-sided heart failure were excluded along with history of cirrhosis, hepatic malignancy, liver transplant, or absence of electrocardiogram/cardiac echocardiogram. Liver histology was reviewed for extent of SD, fibrosis, red blood cell extravasation, nodular regenerative hyperplasia, hepatic peliosis, and hepatocellular plate atrophy (HPA). RESULTS: We identified 88 patients with non-obstructive SD. Inflammatory conditions (32%) were the most common cause. The most common pattern of liver abnormalities was cholestatic (76%). Majority (78%) had localized SD to Zone III. Medication-related SD had higher proportion of portal hypertension (53%), ascites (58%), and median AST (113 U/L) and ALT (90 U/L) levels. Nineteen patients in our study died within one-year after diagnosis of SD, majority from complications related to underlying diseases. CONCLUSION: Significant proportion of SD and HPA exist without impaired hepatic venous outflow. Isolated SD on liver biopsy, in the absence of congestive hepatopathy, requires further evaluation and portal hypertension should be rule out. Baishideng Publishing Group Inc 2018-05-27 2018-05-27 /pmc/articles/PMC5971228/ /pubmed/29844855 http://dx.doi.org/10.4254/wjh.v10.i5.417 Text en ©The Author(s) 2018. Published by Baishideng Publishing Group Inc. All rights reserved. http://creativecommons.org/licenses/by-nc/4.0/ This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. |
spellingShingle | Retrospective Study Sunjaya, Dharma Budi Ramos, Guilherme Piovezani Braga Neto, Manuel Bonfim Lennon, Ryan Mounajjed, Taofic Shah, Vijay Kamath, Patrick Sequeira Simonetto, Douglas Alano Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience |
title | Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience |
title_full | Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience |
title_fullStr | Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience |
title_full_unstemmed | Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience |
title_short | Isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience |
title_sort | isolated hepatic non-obstructive sinusoidal dilatation, 20-year single center experience |
topic | Retrospective Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971228/ https://www.ncbi.nlm.nih.gov/pubmed/29844855 http://dx.doi.org/10.4254/wjh.v10.i5.417 |
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