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An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression

Stress-induced peripheral inflammation contributes to depression-like behaviors in both human and experimental models. PMI 5011, a botanical extract of Artemisia dracunculus L., was previously shown to have multiple bioactivities, including anti-inflammatory activity. In this work, using a repeated...

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Autores principales: Wang, Jun, Fernández, Adelaida Esteban, Tiano, Simoni, Huang, Jing, Floyd, Elizabeth, Poulev, Alexander, Ribnicky, David, Pasinetti, Giulio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971253/
https://www.ncbi.nlm.nih.gov/pubmed/29861834
http://dx.doi.org/10.1155/2018/7418681
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author Wang, Jun
Fernández, Adelaida Esteban
Tiano, Simoni
Huang, Jing
Floyd, Elizabeth
Poulev, Alexander
Ribnicky, David
Pasinetti, Giulio M.
author_facet Wang, Jun
Fernández, Adelaida Esteban
Tiano, Simoni
Huang, Jing
Floyd, Elizabeth
Poulev, Alexander
Ribnicky, David
Pasinetti, Giulio M.
author_sort Wang, Jun
collection PubMed
description Stress-induced peripheral inflammation contributes to depression-like behaviors in both human and experimental models. PMI 5011, a botanical extract of Artemisia dracunculus L., was previously shown to have multiple bioactivities, including anti-inflammatory activity. In this work, using a repeated social defeat stress (RSDS) model of depression, we demonstrate that oral administration of the botanical extract PMI 5011 promotes resilience to RSDS-mediated depression-like phenotypes. We also show that the behavioral improvements are associated with attenuation of stress-mediated induction of inflammatory cytokines in the periphery and alteration of synaptic plasticity in the nucleus accumbens (NAc). Our studies provide experimental evidence that botanical extracts such as PMI 5011, which target pathological mechanisms (i.e., peripheral inflammation) not addressed by currently available antidepressants, could be further developed as novel therapeutics for the treatment of stress disorders and anxiety in humans.
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spelling pubmed-59712532018-06-03 An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression Wang, Jun Fernández, Adelaida Esteban Tiano, Simoni Huang, Jing Floyd, Elizabeth Poulev, Alexander Ribnicky, David Pasinetti, Giulio M. Oxid Med Cell Longev Research Article Stress-induced peripheral inflammation contributes to depression-like behaviors in both human and experimental models. PMI 5011, a botanical extract of Artemisia dracunculus L., was previously shown to have multiple bioactivities, including anti-inflammatory activity. In this work, using a repeated social defeat stress (RSDS) model of depression, we demonstrate that oral administration of the botanical extract PMI 5011 promotes resilience to RSDS-mediated depression-like phenotypes. We also show that the behavioral improvements are associated with attenuation of stress-mediated induction of inflammatory cytokines in the periphery and alteration of synaptic plasticity in the nucleus accumbens (NAc). Our studies provide experimental evidence that botanical extracts such as PMI 5011, which target pathological mechanisms (i.e., peripheral inflammation) not addressed by currently available antidepressants, could be further developed as novel therapeutics for the treatment of stress disorders and anxiety in humans. Hindawi 2018-05-13 /pmc/articles/PMC5971253/ /pubmed/29861834 http://dx.doi.org/10.1155/2018/7418681 Text en Copyright © 2018 Jun Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Jun
Fernández, Adelaida Esteban
Tiano, Simoni
Huang, Jing
Floyd, Elizabeth
Poulev, Alexander
Ribnicky, David
Pasinetti, Giulio M.
An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression
title An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression
title_full An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression
title_fullStr An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression
title_full_unstemmed An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression
title_short An Extract of Artemisia dracunculus L. Promotes Psychological Resilience in a Mouse Model of Depression
title_sort extract of artemisia dracunculus l. promotes psychological resilience in a mouse model of depression
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971253/
https://www.ncbi.nlm.nih.gov/pubmed/29861834
http://dx.doi.org/10.1155/2018/7418681
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