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Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality?

The presence of a polymorphonuclear neutrophil infiltrate in periprosthetic tissues has been shown to correlate closely with the diagnosis of septic implant failure. The histological criterion considered by the Musculoskeletal Infection Society to be diagnostic of periprosthetic joint infection is “...

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Detalles Bibliográficos
Autores principales: Bori, G., McNally, M. A., Athanasou, N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971260/
https://www.ncbi.nlm.nih.gov/pubmed/29862251
http://dx.doi.org/10.1155/2018/1412701
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author Bori, G.
McNally, M. A.
Athanasou, N.
author_facet Bori, G.
McNally, M. A.
Athanasou, N.
author_sort Bori, G.
collection PubMed
description The presence of a polymorphonuclear neutrophil infiltrate in periprosthetic tissues has been shown to correlate closely with the diagnosis of septic implant failure. The histological criterion considered by the Musculoskeletal Infection Society to be diagnostic of periprosthetic joint infection is “greater than five neutrophils per high-power field in five high-power fields observed from histologic analysis of periprosthetic tissue at ×400 magnification.” Surgeons and pathologists should be aware of the qualifications introduced by different authors during the last years in the histological techniques, samples for histological study, cutoffs used for the diagnosis of infection, and types of patients studied. Recently, immunohistochemistry and histochemistry studies have appeared which suggest that the cutoff point of five polymorphonuclear neutrophils in five high-power fields is too high for the diagnosis of many periprosthetic joint infections. Therefore, morphomolecular techniques could help in the future to achieve a more reliable histological diagnosis of periprosthetic joint infection.
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spelling pubmed-59712602018-06-03 Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality? Bori, G. McNally, M. A. Athanasou, N. Biomed Res Int Review Article The presence of a polymorphonuclear neutrophil infiltrate in periprosthetic tissues has been shown to correlate closely with the diagnosis of septic implant failure. The histological criterion considered by the Musculoskeletal Infection Society to be diagnostic of periprosthetic joint infection is “greater than five neutrophils per high-power field in five high-power fields observed from histologic analysis of periprosthetic tissue at ×400 magnification.” Surgeons and pathologists should be aware of the qualifications introduced by different authors during the last years in the histological techniques, samples for histological study, cutoffs used for the diagnosis of infection, and types of patients studied. Recently, immunohistochemistry and histochemistry studies have appeared which suggest that the cutoff point of five polymorphonuclear neutrophils in five high-power fields is too high for the diagnosis of many periprosthetic joint infections. Therefore, morphomolecular techniques could help in the future to achieve a more reliable histological diagnosis of periprosthetic joint infection. Hindawi 2018-05-13 /pmc/articles/PMC5971260/ /pubmed/29862251 http://dx.doi.org/10.1155/2018/1412701 Text en Copyright © 2018 G. Bori et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bori, G.
McNally, M. A.
Athanasou, N.
Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality?
title Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality?
title_full Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality?
title_fullStr Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality?
title_full_unstemmed Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality?
title_short Histopathology in Periprosthetic Joint Infection: When Will the Morphomolecular Diagnosis Be a Reality?
title_sort histopathology in periprosthetic joint infection: when will the morphomolecular diagnosis be a reality?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971260/
https://www.ncbi.nlm.nih.gov/pubmed/29862251
http://dx.doi.org/10.1155/2018/1412701
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