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Reduced NLRP3 Gene Expression Limits the IL-1β Cleavage via Inflammasome in Monocytes from Severely Injured Trauma Patients

OBJECTIVE: Traumatic injury or severe surgery leads to a profound immune response with a diminished functionality of monocytes and subsequently their IL-1β release. IL-1β plays an important role in host immunity and protection against infections. Its biological activation via IL-1β-precursor process...

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Detalles Bibliográficos
Autores principales:	Kany, Shinwan, Horstmann, Johann-Philipp, Sturm, Ramona, Mörs, Katharina, Relja, Borna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971319/ https://www.ncbi.nlm.nih.gov/pubmed/29861655 http://dx.doi.org/10.1155/2018/1752836

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