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Collagen I and III in women with diastasis recti

OBJECTIVES: Interest in elucidating the etiology of hernias has encouraged countless studies of musculoaponeurotic structures in individuals with and without hernias. Studies of hernia patients have firmly demonstrated a correlation between hernias and collagen alterations in their fascia. Diastasis...

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Autores principales: Blotta, Rosa Maria, Costa, Sirlei dos Santos, Trindade, Eduardo Neubarth, Meurer, Luise, Maciel-Trindade, Manoel Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971415/
https://www.ncbi.nlm.nih.gov/pubmed/29898006
http://dx.doi.org/10.6061/clinics/2018/e319
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author Blotta, Rosa Maria
Costa, Sirlei dos Santos
Trindade, Eduardo Neubarth
Meurer, Luise
Maciel-Trindade, Manoel Roberto
author_facet Blotta, Rosa Maria
Costa, Sirlei dos Santos
Trindade, Eduardo Neubarth
Meurer, Luise
Maciel-Trindade, Manoel Roberto
author_sort Blotta, Rosa Maria
collection PubMed
description OBJECTIVES: Interest in elucidating the etiology of hernias has encouraged countless studies of musculoaponeurotic structures in individuals with and without hernias. Studies of hernia patients have firmly demonstrated a correlation between hernias and collagen alterations in their fascia. Diastasis recti is an increased width of the abdominal midline that is exclusively composed of interlacing aponeurotic expansions of the anterolateral abdominal muscles. The condition is common among women undergoing abdominoplasty, and many factors, not only mechanical, play a role. The goal of this study is to evaluate and compare collagen type I and III levels in the midline fascia of women with and without diastasis recti to report their possible influence on this condition. METHODS: This is a case-control study nested within a surgical cohort of 18 women with diastasis recti and 18 women without the condition (cases and controls, respectively). Fascia from the midline of the abdominal wall was collected and analyzed through immunohistochemistry using polyclonal antibodies to collagen type I and III. RESULTS: Both type I and type III collagen were less abundant in women with diastasis recti than in those without the condition, and the difference was statistically significant (p<0.001). CONCLUSION: Low collagen type I and type III levels in the midline of the abdominal wall may play a key role in the development of diastasis recti.
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spelling pubmed-59714152018-05-30 Collagen I and III in women with diastasis recti Blotta, Rosa Maria Costa, Sirlei dos Santos Trindade, Eduardo Neubarth Meurer, Luise Maciel-Trindade, Manoel Roberto Clinics (Sao Paulo) Original Article OBJECTIVES: Interest in elucidating the etiology of hernias has encouraged countless studies of musculoaponeurotic structures in individuals with and without hernias. Studies of hernia patients have firmly demonstrated a correlation between hernias and collagen alterations in their fascia. Diastasis recti is an increased width of the abdominal midline that is exclusively composed of interlacing aponeurotic expansions of the anterolateral abdominal muscles. The condition is common among women undergoing abdominoplasty, and many factors, not only mechanical, play a role. The goal of this study is to evaluate and compare collagen type I and III levels in the midline fascia of women with and without diastasis recti to report their possible influence on this condition. METHODS: This is a case-control study nested within a surgical cohort of 18 women with diastasis recti and 18 women without the condition (cases and controls, respectively). Fascia from the midline of the abdominal wall was collected and analyzed through immunohistochemistry using polyclonal antibodies to collagen type I and III. RESULTS: Both type I and type III collagen were less abundant in women with diastasis recti than in those without the condition, and the difference was statistically significant (p<0.001). CONCLUSION: Low collagen type I and type III levels in the midline of the abdominal wall may play a key role in the development of diastasis recti. Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo 2018-05-28 2018 /pmc/articles/PMC5971415/ /pubmed/29898006 http://dx.doi.org/10.6061/clinics/2018/e319 Text en Copyright © 2018 CLINICS http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium or format, provided the original work is properly cited.
spellingShingle Original Article
Blotta, Rosa Maria
Costa, Sirlei dos Santos
Trindade, Eduardo Neubarth
Meurer, Luise
Maciel-Trindade, Manoel Roberto
Collagen I and III in women with diastasis recti
title Collagen I and III in women with diastasis recti
title_full Collagen I and III in women with diastasis recti
title_fullStr Collagen I and III in women with diastasis recti
title_full_unstemmed Collagen I and III in women with diastasis recti
title_short Collagen I and III in women with diastasis recti
title_sort collagen i and iii in women with diastasis recti
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971415/
https://www.ncbi.nlm.nih.gov/pubmed/29898006
http://dx.doi.org/10.6061/clinics/2018/e319
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