Selective inhibition of intestinal guanosine 3′,5′-cyclic monophosphate signaling by small-molecule protein kinase inhibitors

The guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) serine/threonine kinase relays signaling through guanylyl cyclase C (GCC) to control intestinal fluid homeostasis. Here, we report the discovery of small-molecule inhibitors of cGKII. These inhibitors were imidazole-...

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Detalles Bibliográficos
Autores principales: Bijvelds, Marcel J. C., Tresadern, Gary, Hellemans, Ann, Smans, Karine, Nieuwenhuijze, Natascha D. A., Meijsen, Kelly F., Bongartz, Jean-Pierre, Ver Donck, Luc, de Jonge, Hugo R., Schuurkes, Jan A. J., De Maeyer, Joris H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2018
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971447/
https://www.ncbi.nlm.nih.gov/pubmed/29653944
http://dx.doi.org/10.1074/jbc.RA118.002835

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