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Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer

OBJECTIVE: To demonstrate the correlation between nuclear and cytoplasmic G protein-coupled oestrogen receptor (GPR30) expression and clinicopathological features and outcome in patients with ovarian cancer. METHODS: Nuclear and cytoplasmic GPR30 expressions were determined using immunohistochemistr...

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Autores principales: Zhu, Cai-xia, Xiong, Wei, Wang, Ma-lie, Yang, Juan, Shi, Hui-juan, Chen, Han-qing, Niu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971494/
https://www.ncbi.nlm.nih.gov/pubmed/29239277
http://dx.doi.org/10.1177/0300060517717625
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author Zhu, Cai-xia
Xiong, Wei
Wang, Ma-lie
Yang, Juan
Shi, Hui-juan
Chen, Han-qing
Niu, Gang
author_facet Zhu, Cai-xia
Xiong, Wei
Wang, Ma-lie
Yang, Juan
Shi, Hui-juan
Chen, Han-qing
Niu, Gang
author_sort Zhu, Cai-xia
collection PubMed
description OBJECTIVE: To demonstrate the correlation between nuclear and cytoplasmic G protein-coupled oestrogen receptor (GPR30) expression and clinicopathological features and outcome in patients with ovarian cancer. METHODS: Nuclear and cytoplasmic GPR30 expressions were determined using immunohistochemistry to identify the intracellular location in tissues from patients with ovarian cancer. Data were correlated with clinicopathological characteristics and outcomes. RESULTS: Tissue samples were obtained from 110 patients with epithelial ovarian cancer between 2005 and 2010. Nuclear GPR30 was significantly more frequent in the group of patients with recurrence. The presence of nuclear GPR30 predicted lower overall survival) and 5-year progression-free survival in all patients with ovarian cancer and overall survival in patients with high grade ovarian cancer. Cytoplasmic GPR30 was observed significantly more often in advanced ovarian cancer and did not predict survival. CONCLUSION: This study showed that nuclear GPR30 is an independent negative prognostic indicator in patients with ovarian cancer, especially in those with a high grade malignancy.
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spelling pubmed-59714942018-05-31 Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer Zhu, Cai-xia Xiong, Wei Wang, Ma-lie Yang, Juan Shi, Hui-juan Chen, Han-qing Niu, Gang J Int Med Res Research Reports OBJECTIVE: To demonstrate the correlation between nuclear and cytoplasmic G protein-coupled oestrogen receptor (GPR30) expression and clinicopathological features and outcome in patients with ovarian cancer. METHODS: Nuclear and cytoplasmic GPR30 expressions were determined using immunohistochemistry to identify the intracellular location in tissues from patients with ovarian cancer. Data were correlated with clinicopathological characteristics and outcomes. RESULTS: Tissue samples were obtained from 110 patients with epithelial ovarian cancer between 2005 and 2010. Nuclear GPR30 was significantly more frequent in the group of patients with recurrence. The presence of nuclear GPR30 predicted lower overall survival) and 5-year progression-free survival in all patients with ovarian cancer and overall survival in patients with high grade ovarian cancer. Cytoplasmic GPR30 was observed significantly more often in advanced ovarian cancer and did not predict survival. CONCLUSION: This study showed that nuclear GPR30 is an independent negative prognostic indicator in patients with ovarian cancer, especially in those with a high grade malignancy. SAGE Publications 2017-09-12 2018-02 /pmc/articles/PMC5971494/ /pubmed/29239277 http://dx.doi.org/10.1177/0300060517717625 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Reports
Zhu, Cai-xia
Xiong, Wei
Wang, Ma-lie
Yang, Juan
Shi, Hui-juan
Chen, Han-qing
Niu, Gang
Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer
title Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer
title_full Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer
title_fullStr Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer
title_full_unstemmed Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer
title_short Nuclear G protein-coupled oestrogen receptor (GPR30) predicts poor survival in patients with ovarian cancer
title_sort nuclear g protein-coupled oestrogen receptor (gpr30) predicts poor survival in patients with ovarian cancer
topic Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971494/
https://www.ncbi.nlm.nih.gov/pubmed/29239277
http://dx.doi.org/10.1177/0300060517717625
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