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Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy

OBJECTIVE: To investigate the basal amino acid metabolism and impact of growth hormone (GH) therapy in short-stature children born small for gestational age (short SGA children). METHODS: In this age-matched case-control study, the basal blood levels of amino acids, asymmetric dimethylarginine (ADMA...

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Autores principales: Nagasaka, Hironori, Morioka, Ichiro, Takuwa, Mayuko, Nakacho, Mariko, Yoshida, Mayumi, Ishida, Akihito, Hirayama, Satoshi, Miida, Takashi, Tsukahara, Hirokazu, Yorifuji, Tohru, Iijima, Kazumoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971506/
https://www.ncbi.nlm.nih.gov/pubmed/28974136
http://dx.doi.org/10.1177/0300060517723183
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author Nagasaka, Hironori
Morioka, Ichiro
Takuwa, Mayuko
Nakacho, Mariko
Yoshida, Mayumi
Ishida, Akihito
Hirayama, Satoshi
Miida, Takashi
Tsukahara, Hirokazu
Yorifuji, Tohru
Iijima, Kazumoto
author_facet Nagasaka, Hironori
Morioka, Ichiro
Takuwa, Mayuko
Nakacho, Mariko
Yoshida, Mayumi
Ishida, Akihito
Hirayama, Satoshi
Miida, Takashi
Tsukahara, Hirokazu
Yorifuji, Tohru
Iijima, Kazumoto
author_sort Nagasaka, Hironori
collection PubMed
description OBJECTIVE: To investigate the basal amino acid metabolism and impact of growth hormone (GH) therapy in short-stature children born small for gestational age (short SGA children). METHODS: In this age-matched case-control study, the basal blood levels of amino acids, asymmetric dimethylarginine (ADMA), and nitrite/nitrate (NOx) were compared between 24 short SGA children and 25 age-matched normal children. Changes in these parameters were assessed for 12 months in 12 short SGA children initiating GH therapy (Group A) and 12 age-matched short SGA children without GH therapy (Group B). RESULTS: The arginine levels were significantly lower in the short SGA than in normal children. The ADMA levels were significantly higher and NOx levels were significantly lower in the short SGA than normal children. In Group A, the ADMA level was significantly lower and NOx level was significantly higher at 6 months than at baseline. At 12 months, the ADMA level in Group A began to increase, but the NOx level remained the same. Group B showed no significant changes. CONCLUSIONS: This study is the first to show that ADMA is promoted and nitric oxide is suppressed in short SGA children and that GH therapy affects the production of ADMA and nitric oxide.
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spelling pubmed-59715062018-05-31 Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy Nagasaka, Hironori Morioka, Ichiro Takuwa, Mayuko Nakacho, Mariko Yoshida, Mayumi Ishida, Akihito Hirayama, Satoshi Miida, Takashi Tsukahara, Hirokazu Yorifuji, Tohru Iijima, Kazumoto J Int Med Res Research Reports OBJECTIVE: To investigate the basal amino acid metabolism and impact of growth hormone (GH) therapy in short-stature children born small for gestational age (short SGA children). METHODS: In this age-matched case-control study, the basal blood levels of amino acids, asymmetric dimethylarginine (ADMA), and nitrite/nitrate (NOx) were compared between 24 short SGA children and 25 age-matched normal children. Changes in these parameters were assessed for 12 months in 12 short SGA children initiating GH therapy (Group A) and 12 age-matched short SGA children without GH therapy (Group B). RESULTS: The arginine levels were significantly lower in the short SGA than in normal children. The ADMA levels were significantly higher and NOx levels were significantly lower in the short SGA than normal children. In Group A, the ADMA level was significantly lower and NOx level was significantly higher at 6 months than at baseline. At 12 months, the ADMA level in Group A began to increase, but the NOx level remained the same. Group B showed no significant changes. CONCLUSIONS: This study is the first to show that ADMA is promoted and nitric oxide is suppressed in short SGA children and that GH therapy affects the production of ADMA and nitric oxide. SAGE Publications 2017-10-04 2018-02 /pmc/articles/PMC5971506/ /pubmed/28974136 http://dx.doi.org/10.1177/0300060517723183 Text en © The Author(s) 2017 http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research Reports
Nagasaka, Hironori
Morioka, Ichiro
Takuwa, Mayuko
Nakacho, Mariko
Yoshida, Mayumi
Ishida, Akihito
Hirayama, Satoshi
Miida, Takashi
Tsukahara, Hirokazu
Yorifuji, Tohru
Iijima, Kazumoto
Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy
title Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy
title_full Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy
title_fullStr Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy
title_full_unstemmed Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy
title_short Blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy
title_sort blood asymmetric dimethylarginine and nitrite/nitrate concentrations in short-stature children born small for gestational age with and without growth hormone therapy
topic Research Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971506/
https://www.ncbi.nlm.nih.gov/pubmed/28974136
http://dx.doi.org/10.1177/0300060517723183
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