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Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels

The imidazopyridines are a promising new class of antitubercular agents with potent activity in vitro and in vivo. We isolated mutants of Mycobacterium tuberculosis resistant to a representative imidazopyridine; the mutants had large shifts (>20-fold) in MIC. Whole-genome sequencing revealed muta...

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Detalles Bibliográficos
Autores principales:	O'Malley, Theresa, Alling, Torey, Early, Julie V., Wescott, Heather A., Kumar, Anuradha, Moraski, Garrett C., Miller, Marvin J., Masquelin, Thierry, Hipskind, Philip A., Parish, Tanya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Mechanisms of Resistance
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971599/ https://www.ncbi.nlm.nih.gov/pubmed/29632008 http://dx.doi.org/10.1128/AAC.02439-17

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