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Pharmacokinetics and Pharmacodynamics of Fosfomycin and Its Activity against Extended-Spectrum-β-Lactamase-, Plasmid-Mediated AmpC-, and Carbapenemase-Producing Escherichia coli in a Murine Urinary Tract Infection Model

Fosfomycin has become an attractive treatment alternative for urinary tract infections (UTIs) due to increasing multidrug resistance (MDR) in Escherichia coli. In this study, we evaluated the pharmacokinetic (PK) and pharmacodynamic (PD) indices of fosfomycin and its in vivo activity in an experimen...

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Detalles Bibliográficos
Autores principales:	Zykov, Ilya Nikolaevich, Samuelsen, Ørjan, Jakobsen, Lotte, Småbrekke, Lars, Andersson, Dan I., Sundsfjord, Arnfinn, Frimodt-Møller, Niels
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971609/ https://www.ncbi.nlm.nih.gov/pubmed/29581117 http://dx.doi.org/10.1128/AAC.02560-17

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