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Experience with β-D-Glucan Assay in the Management of Critically ill Patients with High Risk of Invasive Candidiasis: An Observational Study

BACKGROUND: The (1,3)-β-D-glucan assay (BDG) is recommended for the early diagnosis of invasive candidiasis (IC). METHODS: Records of 154 critically ill adults with suspected IC, on whom BDG was done, were analyzed. Patients were divided into three groups: Group A (confirmed IC), Group B (alternativ...

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Autores principales: Bansal, Nitin, Gopalakrishnan, Ram, Sethuraman, Nandini, Ramakrishnan, Nagarajan, Nambi, P. Senthur, Kumar, D. Suresh, Madhumitha, R., Thirunarayan, M. A., Ramasubramanian, V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971648/
https://www.ncbi.nlm.nih.gov/pubmed/29910549
http://dx.doi.org/10.4103/ijccm.IJCCM_4_18
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author Bansal, Nitin
Gopalakrishnan, Ram
Sethuraman, Nandini
Ramakrishnan, Nagarajan
Nambi, P. Senthur
Kumar, D. Suresh
Madhumitha, R.
Thirunarayan, M. A.
Ramasubramanian, V.
author_facet Bansal, Nitin
Gopalakrishnan, Ram
Sethuraman, Nandini
Ramakrishnan, Nagarajan
Nambi, P. Senthur
Kumar, D. Suresh
Madhumitha, R.
Thirunarayan, M. A.
Ramasubramanian, V.
author_sort Bansal, Nitin
collection PubMed
description BACKGROUND: The (1,3)-β-D-glucan assay (BDG) is recommended for the early diagnosis of invasive candidiasis (IC). METHODS: Records of 154 critically ill adults with suspected IC, on whom BDG was done, were analyzed. Patients were divided into three groups: Group A (confirmed IC), Group B (alternative diagnosis or cause of severe sepsis), and Group C (high candidal score and positive BDG [>80 pg/mL] but without a confirmed diagnosis of IC). RESULTS: Mean BDG levels were significantly higher in Group A (n = 32) as compared to Group B (n = 60) and Group C (n = 62) (448.75 ± 88.30 vs. 144.46 ± 82.49 vs. 292.90 ± 137.0 pg/mL; P < 0.001). Discontinuation of empiric antifungal therapy based on a value <80 resulted in cost savings of 14,000 INR per day per patient. CONCLUSION: A BDG value of <80 pg/ml facilitates early discontinuation of empirical antifungal therapy, with considerable cost savings.
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spelling pubmed-59716482018-06-15 Experience with β-D-Glucan Assay in the Management of Critically ill Patients with High Risk of Invasive Candidiasis: An Observational Study Bansal, Nitin Gopalakrishnan, Ram Sethuraman, Nandini Ramakrishnan, Nagarajan Nambi, P. Senthur Kumar, D. Suresh Madhumitha, R. Thirunarayan, M. A. Ramasubramanian, V. Indian J Crit Care Med Brief Communication BACKGROUND: The (1,3)-β-D-glucan assay (BDG) is recommended for the early diagnosis of invasive candidiasis (IC). METHODS: Records of 154 critically ill adults with suspected IC, on whom BDG was done, were analyzed. Patients were divided into three groups: Group A (confirmed IC), Group B (alternative diagnosis or cause of severe sepsis), and Group C (high candidal score and positive BDG [>80 pg/mL] but without a confirmed diagnosis of IC). RESULTS: Mean BDG levels were significantly higher in Group A (n = 32) as compared to Group B (n = 60) and Group C (n = 62) (448.75 ± 88.30 vs. 144.46 ± 82.49 vs. 292.90 ± 137.0 pg/mL; P < 0.001). Discontinuation of empiric antifungal therapy based on a value <80 resulted in cost savings of 14,000 INR per day per patient. CONCLUSION: A BDG value of <80 pg/ml facilitates early discontinuation of empirical antifungal therapy, with considerable cost savings. Medknow Publications & Media Pvt Ltd 2018-05 /pmc/articles/PMC5971648/ /pubmed/29910549 http://dx.doi.org/10.4103/ijccm.IJCCM_4_18 Text en Copyright: © 2018 Indian Journal of Critical Care Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Brief Communication
Bansal, Nitin
Gopalakrishnan, Ram
Sethuraman, Nandini
Ramakrishnan, Nagarajan
Nambi, P. Senthur
Kumar, D. Suresh
Madhumitha, R.
Thirunarayan, M. A.
Ramasubramanian, V.
Experience with β-D-Glucan Assay in the Management of Critically ill Patients with High Risk of Invasive Candidiasis: An Observational Study
title Experience with β-D-Glucan Assay in the Management of Critically ill Patients with High Risk of Invasive Candidiasis: An Observational Study
title_full Experience with β-D-Glucan Assay in the Management of Critically ill Patients with High Risk of Invasive Candidiasis: An Observational Study
title_fullStr Experience with β-D-Glucan Assay in the Management of Critically ill Patients with High Risk of Invasive Candidiasis: An Observational Study
title_full_unstemmed Experience with β-D-Glucan Assay in the Management of Critically ill Patients with High Risk of Invasive Candidiasis: An Observational Study
title_short Experience with β-D-Glucan Assay in the Management of Critically ill Patients with High Risk of Invasive Candidiasis: An Observational Study
title_sort experience with β-d-glucan assay in the management of critically ill patients with high risk of invasive candidiasis: an observational study
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5971648/
https://www.ncbi.nlm.nih.gov/pubmed/29910549
http://dx.doi.org/10.4103/ijccm.IJCCM_4_18
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