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Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust valida...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972004/ https://www.ncbi.nlm.nih.gov/pubmed/28135244 http://dx.doi.org/10.1038/ng.3768 |
| _version_ | 1783326367923830784 |
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| author | Warren, Helen R Evangelou, Evangelos Cabrera, Claudia P Gao, He Ren, Meixia Mifsud, Borbala Ntalla, Ioanna Surendran, Praveen Liu, Chunyu Cook, James P Kraja, Aldi T Drenos, Fotios Loh, Marie Verweij, Niek Marten, Jonathan Karaman, Ibrahim Segura Lepe, Marcelo P O’Reilly, Paul F Knight, Joanne Snieder, Harold Kato, Norihiro He, Jiang Tai, E Shyong Said, M Abdullah Porteous, David Alver, Maris Poulter, Neil Farrall, Martin Gansevoort, Ron T Padmanabhan, Sandosh Mägi, Reedik Stanton, Alice Connell, John Bakker, Stephan J L Metspalu, Andres Shields, Denis C Thom, Simon Brown, Morris Sever, Peter Esko, Tõnu Hayward, Caroline van der Harst, Pim Saleheen, Danish Chowdhury, Rajiv Chambers, John C Chasman, Daniel I Chakravarti, Aravinda Newton-Cheh, Christopher Lindgren, Cecilia M Levy, Daniel Kooner, Jaspal S Keavney, Bernard Tomaszewski, Maciej Samani, Nilesh J Howson, Joanna M M Tobin, Martin D Munroe, Patricia B Ehret, Georg B Wain, Louise V Barnes, Michael R Tzoulaki, Ioanna Caulfield, Mark J Elliott, Paul |
| author_facet | Warren, Helen R Evangelou, Evangelos Cabrera, Claudia P Gao, He Ren, Meixia Mifsud, Borbala Ntalla, Ioanna Surendran, Praveen Liu, Chunyu Cook, James P Kraja, Aldi T Drenos, Fotios Loh, Marie Verweij, Niek Marten, Jonathan Karaman, Ibrahim Segura Lepe, Marcelo P O’Reilly, Paul F Knight, Joanne Snieder, Harold Kato, Norihiro He, Jiang Tai, E Shyong Said, M Abdullah Porteous, David Alver, Maris Poulter, Neil Farrall, Martin Gansevoort, Ron T Padmanabhan, Sandosh Mägi, Reedik Stanton, Alice Connell, John Bakker, Stephan J L Metspalu, Andres Shields, Denis C Thom, Simon Brown, Morris Sever, Peter Esko, Tõnu Hayward, Caroline van der Harst, Pim Saleheen, Danish Chowdhury, Rajiv Chambers, John C Chasman, Daniel I Chakravarti, Aravinda Newton-Cheh, Christopher Lindgren, Cecilia M Levy, Daniel Kooner, Jaspal S Keavney, Bernard Tomaszewski, Maciej Samani, Nilesh J Howson, Joanna M M Tobin, Martin D Munroe, Patricia B Ehret, Georg B Wain, Louise V Barnes, Michael R Tzoulaki, Ioanna Caulfield, Mark J Elliott, Paul |
| collection | PubMed |
| description | Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. Combined with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure raising genetic variants on future cardiovascular disease risk. |
| format | Online Article Text |
| id | pubmed-5972004 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59720042018-05-28 Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk Warren, Helen R Evangelou, Evangelos Cabrera, Claudia P Gao, He Ren, Meixia Mifsud, Borbala Ntalla, Ioanna Surendran, Praveen Liu, Chunyu Cook, James P Kraja, Aldi T Drenos, Fotios Loh, Marie Verweij, Niek Marten, Jonathan Karaman, Ibrahim Segura Lepe, Marcelo P O’Reilly, Paul F Knight, Joanne Snieder, Harold Kato, Norihiro He, Jiang Tai, E Shyong Said, M Abdullah Porteous, David Alver, Maris Poulter, Neil Farrall, Martin Gansevoort, Ron T Padmanabhan, Sandosh Mägi, Reedik Stanton, Alice Connell, John Bakker, Stephan J L Metspalu, Andres Shields, Denis C Thom, Simon Brown, Morris Sever, Peter Esko, Tõnu Hayward, Caroline van der Harst, Pim Saleheen, Danish Chowdhury, Rajiv Chambers, John C Chasman, Daniel I Chakravarti, Aravinda Newton-Cheh, Christopher Lindgren, Cecilia M Levy, Daniel Kooner, Jaspal S Keavney, Bernard Tomaszewski, Maciej Samani, Nilesh J Howson, Joanna M M Tobin, Martin D Munroe, Patricia B Ehret, Georg B Wain, Louise V Barnes, Michael R Tzoulaki, Ioanna Caulfield, Mark J Elliott, Paul Nat Genet Article Elevated blood pressure is the leading heritable risk factor for cardiovascular disease worldwide. We report genetic association of blood pressure (systolic, diastolic, pulse pressure) among UK Biobank participants of European ancestry with independent replication in other cohorts, and robust validation of 107 independent loci. We also identify new independent variants at 11 previously reported blood pressure loci. Combined with results from a range of in silico functional analyses and wet bench experiments, our findings highlight new biological pathways for blood pressure regulation enriched for genes expressed in vascular tissues and identify potential therapeutic targets for hypertension. Results from genetic risk score models raise the possibility of a precision medicine approach through early lifestyle intervention to offset the impact of blood pressure raising genetic variants on future cardiovascular disease risk. 2017-01-30 2017-03 /pmc/articles/PMC5972004/ /pubmed/28135244 http://dx.doi.org/10.1038/ng.3768 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Warren, Helen R Evangelou, Evangelos Cabrera, Claudia P Gao, He Ren, Meixia Mifsud, Borbala Ntalla, Ioanna Surendran, Praveen Liu, Chunyu Cook, James P Kraja, Aldi T Drenos, Fotios Loh, Marie Verweij, Niek Marten, Jonathan Karaman, Ibrahim Segura Lepe, Marcelo P O’Reilly, Paul F Knight, Joanne Snieder, Harold Kato, Norihiro He, Jiang Tai, E Shyong Said, M Abdullah Porteous, David Alver, Maris Poulter, Neil Farrall, Martin Gansevoort, Ron T Padmanabhan, Sandosh Mägi, Reedik Stanton, Alice Connell, John Bakker, Stephan J L Metspalu, Andres Shields, Denis C Thom, Simon Brown, Morris Sever, Peter Esko, Tõnu Hayward, Caroline van der Harst, Pim Saleheen, Danish Chowdhury, Rajiv Chambers, John C Chasman, Daniel I Chakravarti, Aravinda Newton-Cheh, Christopher Lindgren, Cecilia M Levy, Daniel Kooner, Jaspal S Keavney, Bernard Tomaszewski, Maciej Samani, Nilesh J Howson, Joanna M M Tobin, Martin D Munroe, Patricia B Ehret, Georg B Wain, Louise V Barnes, Michael R Tzoulaki, Ioanna Caulfield, Mark J Elliott, Paul Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk |
| title | Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk |
| title_full | Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk |
| title_fullStr | Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk |
| title_full_unstemmed | Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk |
| title_short | Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk |
| title_sort | genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972004/ https://www.ncbi.nlm.nih.gov/pubmed/28135244 http://dx.doi.org/10.1038/ng.3768 |
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