Comprehensive Antiretroviral Restriction Factor Profiling Reveals the Evolutionary Imprint of the ex Vivo and in Vivo IFN-β Response in HTLV-1-Associated Neuroinflammation

HTLV-1-Associated Myelopathy (HAM/TSP) is a progressive neuroinflammatory disorder for which no disease-modifying treatment exists. Modest clinical benefit from type I interferons (IFN-α/β) in HAM/TSP contrasts with its recently identified IFN-inducible gene signature. In addition, IFN-α treatment i...

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Detalles Bibliográficos
Autores principales: Leal, Fabio E., Menezes, Soraya Maria, Costa, Emanuela A. S., Brailey, Phillip M., Gama, Lucio, Segurado, Aluisio C., Kallas, Esper G., Nixon, Douglas F., Dierckx, Tim, Khouri, Ricardo, Vercauteren, Jurgen, Galvão-Castro, Bernardo, Saraiva Raposo, Rui Andre, Van Weyenbergh, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972197/
https://www.ncbi.nlm.nih.gov/pubmed/29872426
http://dx.doi.org/10.3389/fmicb.2018.00985

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972197/
https://www.ncbi.nlm.nih.gov/pubmed/29872426
http://dx.doi.org/10.3389/fmicb.2018.00985

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