A Mad2-Mediated Translational Regulatory Mechanism Promoting S-Phase Cyclin Synthesis Controls Origin Firing and Survival to Replication Stress

Cell survival to replication stress depends on the activation of the Mec1(ATR)-Rad53 checkpoint response that protects the integrity of stalled forks and controls the origin firing program. Here we found that Mad2, a member of the spindle assembly checkpoint (SAC), contributes to efficient origin fi...

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Detalles Bibliográficos
Autores principales: Gay, Sophie, Piccini, Daniele, Bruhn, Christopher, Ricciardi, Sara, Soffientini, Paolo, Carotenuto, Walter, Biffo, Stefano, Foiani, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972228/
https://www.ncbi.nlm.nih.gov/pubmed/29775579
http://dx.doi.org/10.1016/j.molcel.2018.04.020

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