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The CST Complex Mediates End Protection at Double-Strand Breaks and Promotes PARP Inhibitor Sensitivity in BRCA1-Deficient Cells

Selective elimination of BRCA1-deficient cells by inhibitors of poly(ADP-ribose) polymerase (PARP) is a prime example of the concept of synthetic lethality in cancer therapy. This interaction is counteracted by the restoration of BRCA1-independent homologous recombination through loss of factors suc...

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Detalles Bibliográficos
Autores principales:	Barazas, Marco, Annunziato, Stefano, Pettitt, Stephen J., de Krijger, Inge, Ghezraoui, Hind, Roobol, Stefan J., Lutz, Catrin, Frankum, Jessica, Song, Fei Fei, Brough, Rachel, Evers, Bastiaan, Gogola, Ewa, Bhin, Jinhyuk, van de Ven, Marieke, van Gent, Dik C., Jacobs, Jacqueline J.L., Chapman, Ross, Lord, Christopher J., Jonkers, Jos, Rottenberg, Sven
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972230/ https://www.ncbi.nlm.nih.gov/pubmed/29768208 http://dx.doi.org/10.1016/j.celrep.2018.04.046

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