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Polε Instability Drives Replication Stress, Abnormal Development, and Tumorigenesis

DNA polymerase ε (POLE) is a four-subunit complex and the major leading strand polymerase in eukaryotes. Budding yeast orthologs of POLE3 and POLE4 promote Polε processivity in vitro but are dispensable for viability in vivo. Here, we report that POLE4 deficiency in mice destabilizes the entire Polε...

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Detalles Bibliográficos
Autores principales:	Bellelli, Roberto, Borel, Valerie, Logan, Clare, Svendsen, Jennifer, Cox, Danielle E., Nye, Emma, Metcalfe, Kay, O’Connell, Susan M., Stamp, Gordon, Flynn, Helen R., Snijders, Ambrosius P., Lassailly, François, Jackson, Andrew, Boulton, Simon J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972231/ https://www.ncbi.nlm.nih.gov/pubmed/29754823 http://dx.doi.org/10.1016/j.molcel.2018.04.008

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