Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)

It has been observed that many phytochemicals, frequently present in foods or beverages, show potent chemopreventive or therapeutic properties that selectively affect cancer cells. Numerous studies have demonstrated the anticancer activity of xanthohumol (Xn), a prenylated flavonoid isolated from ho...

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Autores principales: Jiang, Chuan-Hao, Sun, Tao-Li, Xiang, Da-Xiong, Wei, Shan-Shan, Li, Wen-Qun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972274/
https://www.ncbi.nlm.nih.gov/pubmed/29872398
http://dx.doi.org/10.3389/fphar.2018.00530
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author Jiang, Chuan-Hao
Sun, Tao-Li
Xiang, Da-Xiong
Wei, Shan-Shan
Li, Wen-Qun
author_facet Jiang, Chuan-Hao
Sun, Tao-Li
Xiang, Da-Xiong
Wei, Shan-Shan
Li, Wen-Qun
author_sort Jiang, Chuan-Hao
collection PubMed
description It has been observed that many phytochemicals, frequently present in foods or beverages, show potent chemopreventive or therapeutic properties that selectively affect cancer cells. Numerous studies have demonstrated the anticancer activity of xanthohumol (Xn), a prenylated flavonoid isolated from hops (Humulus lupulus L.), with a concentration up to 0.96 mg/L in beer. This review aims to summarize the existing studies focusing on the anticancer activity of Xn and its effects on key signaling molecules. Furthermore, the limitations of current studies and challenges for the clinical use of Xn are discussed.
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spelling pubmed-59722742018-06-05 Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.) Jiang, Chuan-Hao Sun, Tao-Li Xiang, Da-Xiong Wei, Shan-Shan Li, Wen-Qun Front Pharmacol Pharmacology It has been observed that many phytochemicals, frequently present in foods or beverages, show potent chemopreventive or therapeutic properties that selectively affect cancer cells. Numerous studies have demonstrated the anticancer activity of xanthohumol (Xn), a prenylated flavonoid isolated from hops (Humulus lupulus L.), with a concentration up to 0.96 mg/L in beer. This review aims to summarize the existing studies focusing on the anticancer activity of Xn and its effects on key signaling molecules. Furthermore, the limitations of current studies and challenges for the clinical use of Xn are discussed. Frontiers Media S.A. 2018-05-22 /pmc/articles/PMC5972274/ /pubmed/29872398 http://dx.doi.org/10.3389/fphar.2018.00530 Text en Copyright © 2018 Jiang, Sun, Xiang, Wei and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Jiang, Chuan-Hao
Sun, Tao-Li
Xiang, Da-Xiong
Wei, Shan-Shan
Li, Wen-Qun
Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)
title Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)
title_full Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)
title_fullStr Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)
title_full_unstemmed Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)
title_short Anticancer Activity and Mechanism of Xanthohumol: A Prenylated Flavonoid From Hops (Humulus lupulus L.)
title_sort anticancer activity and mechanism of xanthohumol: a prenylated flavonoid from hops (humulus lupulus l.)
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972274/
https://www.ncbi.nlm.nih.gov/pubmed/29872398
http://dx.doi.org/10.3389/fphar.2018.00530
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