胸腺瘤合并重症肌无力患者预后的临床研究

BACKGROUND AND OBJECTIVE: Thymoma is frequently associated with myasthenia gravis (MG). However, whether MG is a factor for the outcome of patients with thymoma following complete thymectomy remains unknown. The aim of this study is to investigate the effect of thymoma with MG prognostic factors. METHODS: A retrospective analysis of The Chinese Alliance for Research in Thymomas (ChART) database within 1992-2012 complete cases 875 cases, 20 years follow-up data analysis thymic tumor tissue type credits and MG, Masaoka staging and prognosis, postoperative adjuvant therapy and relationship with the prognosis of surgical removal of the way. RESULTS: Thymic tumor tissue type credit has correlation with MG, difference was statistically significant (χ(2)=24.908, P < 0.001). MG: incidence of B2 type (58/178, 32.58%) > B3 type (65/239, 27.20%) > B1 (27/132, 20.45%) > AB (43/267, 16.10%) > type A, 10.17% (6/59), Masaoka stage has no correlation with MG (χ(2)=0.365, P=1.365). Survival analysis showed that the WHO classification, Masaoka stage associated with prognosis (P < 0.05), and whether the merger MG (χ(2)=0.113, P=0.736), postoperative adjuvant radiotherapy (χ(2)=0.380, P=0.538) has nothing to do with the prognosis, postoperative adjuvant chemotherapy is associated with poor prognosis (χ(2)=14.417, P < 0.001). Whether has nothing to do with the prognosis of the thymus resection (χ(2)=1.548, P=1.548), whether the whole correlated with the curative effect of thymus excision with MG (χ(2)=24.695, P < 0.001). CONCLUSION: Thymoma patients with MG and extended thymectomy have no correlation with prognosis. Extended thymectomy can improve the effect of MG patients.