Systematic evaluation of CRISPR-Cas systems reveals design principles for genome editing in human cells

BACKGROUND: While CRISPR-Cas systems hold tremendous potential for engineering the human genome, it is unclear how well each system performs against one another in both non-homologous end joining (NHEJ)-mediated and homology-directed repair (HDR)-mediated genome editing. RESULTS: We systematically c...

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Detalles Bibliográficos
Autores principales: Wang, Yuanming, Liu, Kaiwen Ivy, Sutrisnoh, Norfala-Aliah Binte, Srinivasan, Harini, Zhang, Junyi, Li, Jia, Zhang, Fan, Lalith, Charles Richard John, Xing, Heyun, Shanmugam, Raghuvaran, Foo, Jia Nee, Yeo, Hwee Ting, Ooi, Kean Hean, Bleckwehl, Tore, Par, Yi Yun Rachel, Lee, Shi Mun, Ismail, Nur Nadiah Binte, Sanwari, Nur Aidah Binti, Lee, Si Ting Vanessa, Lew, Jan, Tan, Meng How
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972437/
https://www.ncbi.nlm.nih.gov/pubmed/29843790
http://dx.doi.org/10.1186/s13059-018-1445-x

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