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Specificity of peptidases secreted by filamentous fungi
Peptidases are enzymes that cleave peptide bonds, yielding proteins and peptides. Enzymes in this class also perform several other functions, regulating the activation or inactivation of target substrates via proteolysis. Owing to these functions, peptidases have been extensively used in industrial...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972931/ https://www.ncbi.nlm.nih.gov/pubmed/28857638 http://dx.doi.org/10.1080/21655979.2017.1373531 |
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author | Hamin Neto, Youssef Ali Abou da Rosa Garzon, Nathália Gonsales Pedezzi, Rafael Cabral, Hamilton |
author_facet | Hamin Neto, Youssef Ali Abou da Rosa Garzon, Nathália Gonsales Pedezzi, Rafael Cabral, Hamilton |
author_sort | Hamin Neto, Youssef Ali Abou |
collection | PubMed |
description | Peptidases are enzymes that cleave peptide bonds, yielding proteins and peptides. Enzymes in this class also perform several other functions, regulating the activation or inactivation of target substrates via proteolysis. Owing to these functions, peptidases have been extensively used in industrial and biotechnological applications. Given their potential functions, it is important to optimize the use of these enzymes, which requires determination of the specificity of each peptidase. The peptidase specificity must be taken into account in choosing a peptidase to catalyze the available protein source within the desired application. The specificity of a peptidase defines the profile of enzyme–substrate interactions, and for this the catalytic site and the arrangement of the amino acid residues involved in peptide bond cleavage need to be known. The catalytic sites of peptidases may be composed of several subsites that interact with amino acid residues for proteolysis. Filamentous fungi produce peptidases with varying specificity, and here we provide a review of those reported to date and their potential applications. |
format | Online Article Text |
id | pubmed-5972931 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-59729312018-09-21 Specificity of peptidases secreted by filamentous fungi Hamin Neto, Youssef Ali Abou da Rosa Garzon, Nathália Gonsales Pedezzi, Rafael Cabral, Hamilton Bioengineered Commentary Peptidases are enzymes that cleave peptide bonds, yielding proteins and peptides. Enzymes in this class also perform several other functions, regulating the activation or inactivation of target substrates via proteolysis. Owing to these functions, peptidases have been extensively used in industrial and biotechnological applications. Given their potential functions, it is important to optimize the use of these enzymes, which requires determination of the specificity of each peptidase. The peptidase specificity must be taken into account in choosing a peptidase to catalyze the available protein source within the desired application. The specificity of a peptidase defines the profile of enzyme–substrate interactions, and for this the catalytic site and the arrangement of the amino acid residues involved in peptide bond cleavage need to be known. The catalytic sites of peptidases may be composed of several subsites that interact with amino acid residues for proteolysis. Filamentous fungi produce peptidases with varying specificity, and here we provide a review of those reported to date and their potential applications. Taylor & Francis 2017-09-21 /pmc/articles/PMC5972931/ /pubmed/28857638 http://dx.doi.org/10.1080/21655979.2017.1373531 Text en © 2018 The Author(s). Published with license by Taylor & Francis http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Commentary Hamin Neto, Youssef Ali Abou da Rosa Garzon, Nathália Gonsales Pedezzi, Rafael Cabral, Hamilton Specificity of peptidases secreted by filamentous fungi |
title | Specificity of peptidases secreted by filamentous fungi |
title_full | Specificity of peptidases secreted by filamentous fungi |
title_fullStr | Specificity of peptidases secreted by filamentous fungi |
title_full_unstemmed | Specificity of peptidases secreted by filamentous fungi |
title_short | Specificity of peptidases secreted by filamentous fungi |
title_sort | specificity of peptidases secreted by filamentous fungi |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5972931/ https://www.ncbi.nlm.nih.gov/pubmed/28857638 http://dx.doi.org/10.1080/21655979.2017.1373531 |
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