吸烟对男性肺癌患者组织学分型的影响及其趋势分析

BACKGROUND AND OBJECTIVE: Studies found that there were changes in histological subtypes of lung cancer patients in China. This study investigated the effect of smoking on lung cancer histology and its trend in Chinese male. METHODS: Demographic, smoking history and histological information about male lung cancer patients diagnosed or treated from 2000 to 2012 was collected from Cancer Hospital, Chinese Academy of Medical Science. Trends of histological subtypes calculated with annual percentage change (APC). RESULTS: A total of 14, 106 patients with lung cancer were enrolled, with smoking 11, 750 cases and non-smoking 2, 356 cases. The main histological type of smoking lung cancer was squamous cell carcinoma (SCC)(39.38%), followed by adenocarcinoma (ADC)(29.85%). Among smokers, the proportion of SCC decreased from 44.19% to 35.50% (APC=-1.9%, P < 0.001), however, the ADC increased from 15.25% to 41.85% (APC=6.8%, P < 0.001). Adenosquamous carcinoma (ASC) was from 4.13% to 0.72% (APC=-14.9%, P < 0.001). In non-smokers, the ADC was 53.86%, and SCC was 16.64%. ADC increased from 38.03% to 67.83% (APC=4.3%, P < 0.001). Distributions of LCC and ASC were scattered. CONCLUSION: Proportion of ADC increased significantly in smoking and non-smoking lung cancer patients, and the relationship between non-smoking factor exposure and lung cancer should be further studied.