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长链非编码RNA在非小细胞肺癌EGFR-TKIs耐药中的研究进展
Most non-small cell lung cancer patients with active epidermal growth factor receptor (EGFR) mutation will eventually acquire drug resistant to EGFR tyrosine kinase inhibitors, such as gefitinib, resulting in disease progression, which involves a variety of complex mechanisms. Up to now, the molecul...
| Formato: | Online Artículo Texto |
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| Lenguaje: | English |
| Publicado: |
中国肺癌杂志编辑部
2018
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973017/ https://www.ncbi.nlm.nih.gov/pubmed/29526180 http://dx.doi.org/10.3779/j.issn.1009-3419.2018.02.06 |
| _version_ | 1783326526355275776 |
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| collection | PubMed |
| description | Most non-small cell lung cancer patients with active epidermal growth factor receptor (EGFR) mutation will eventually acquire drug resistant to EGFR tyrosine kinase inhibitors, such as gefitinib, resulting in disease progression, which involves a variety of complex mechanisms. Up to now, the molecular mechanisms of long non-coding RNAs mediated EGFR-TKIs resistance remains poorly understood. This review aims to outline the current state of information on lncRNAs and progress on its role in EGFR-TKIs resistance in non-small cell lung cancer. |
| format | Online Article Text |
| id | pubmed-5973017 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2018 |
| publisher | 中国肺癌杂志编辑部 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-59730172018-07-06 长链非编码RNA在非小细胞肺癌EGFR-TKIs耐药中的研究进展 Zhongguo Fei Ai Za Zhi 综述 Most non-small cell lung cancer patients with active epidermal growth factor receptor (EGFR) mutation will eventually acquire drug resistant to EGFR tyrosine kinase inhibitors, such as gefitinib, resulting in disease progression, which involves a variety of complex mechanisms. Up to now, the molecular mechanisms of long non-coding RNAs mediated EGFR-TKIs resistance remains poorly understood. This review aims to outline the current state of information on lncRNAs and progress on its role in EGFR-TKIs resistance in non-small cell lung cancer. 中国肺癌杂志编辑部 2018-02-20 /pmc/articles/PMC5973017/ /pubmed/29526180 http://dx.doi.org/10.3779/j.issn.1009-3419.2018.02.06 Text en 版权所有©《中国肺癌杂志》编辑部2018 https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) License. See: https://creativecommons.org/licenses/by/3.0/ |
| spellingShingle | 综述 长链非编码RNA在非小细胞肺癌EGFR-TKIs耐药中的研究进展 |
| title | 长链非编码RNA在非小细胞肺癌EGFR-TKIs耐药中的研究进展 |
| title_full | 长链非编码RNA在非小细胞肺癌EGFR-TKIs耐药中的研究进展 |
| title_fullStr | 长链非编码RNA在非小细胞肺癌EGFR-TKIs耐药中的研究进展 |
| title_full_unstemmed | 长链非编码RNA在非小细胞肺癌EGFR-TKIs耐药中的研究进展 |
| title_short | 长链非编码RNA在非小细胞肺癌EGFR-TKIs耐药中的研究进展 |
| title_sort | 长链非编码rna在非小细胞肺癌egfr-tkis耐药中的研究进展 |
| topic | 综述 |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5973017/ https://www.ncbi.nlm.nih.gov/pubmed/29526180 http://dx.doi.org/10.3779/j.issn.1009-3419.2018.02.06 |
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